专利检索 ap:("ESSENTIAL THERAPEUTICS INC" OR "PLIVA D D") AND inv:"FARADY CHRISTOPHER" 第 1 页

1.

发明公开
8/17 HETEROCYCLIC COMPOUNDS AND USES THEREOF AS D-ALANYL-D-ALANINE LIGASE INHIBITORS 审中-公开
标题翻译： 8/17杂环化合物和它们作为D-丙氨酰-D-丙氨酸连接酶抑制剂

公开(公告)号：EP1411949A4

公开(公告)日：2004-11-24

申请号：EP02759101

申请日：2002-06-28

申请人： ESSENTIAL THERAPEUTICS INC , PLIVA D D

发明人： MOE SCOTT T , ALA PAUL J , PEROLA EMANUELE , FAERMAN CARLOS H , CLEMENT JACOB J , ALI JANID A , WILL PAUL M , MARCHESE SALVATORE A , MAGEE ANDREW S , GAZZANIGA JOHN V , FARADY CHRISTOPHER , NAVIA MANUEL A , CONNELLY PATRICK R

IPC分类号： A61K31/519 , A61K31/525 , A61P31/04 , C07D401/12 , C07D471/04 , C07D475/08 , C07D487/02 , C07D487/04 , C07D519/00 , A61K31/517

CPC分类号： C07D401/12 , C07D471/04 , C07D475/08 , C07D487/04

摘要： The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.