公开(公告)号：EP4116296A1

公开(公告)日：2023-01-11

申请号：EP21765519.0

申请日：2021-03-02

申请人： East China University of Science and Technology ,  Wuhan University

发明人： LI, Honglin ,  XU, Ke ,  LI, Shiliang ,  ZHU, Lili ,  ZHAO, Zhenjiang

IPC分类号： C07D277/50 ,  A61K31/426 ,  A61P31/12

摘要： An application of a novel thiazole derivative in the treatment of an RNA virus infection and the preparation of a drug for treating an RNA virus infection. Specifically, the present invention relates to a use of a compound represented by the following formula I and a pharmaceutical composition containing a compound represented by the following formula I in treating an RNA virus infection and preparing a drug for treating a coronavirus infection.

公开(公告)号：EP3214079B1

公开(公告)日：2020-06-24

申请号：EP15855852.8

申请日：2015-10-30

申请人： East China University Of Science And Technology ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： LI, Honglin ,  JIANG, Hualiang ,  XU, Yufang ,  LI, Jia ,  ZHAO, Zhenjiang ,  LI, Jingya ,  XU, Hongling ,  LI, Shiliang

IPC分类号： C07D311/92 ,  C07D405/04 ,  C07D417/04 ,  C07D221/10 ,  C07D335/04 ,  A61K31/352 ,  A61K31/5377 ,  A61P3/00 ,  A61P3/10 ,  A61P7/10 ,  A61P29/00

公开(公告)号：EP3906969A1

公开(公告)日：2021-11-10

申请号：EP20822935.1

申请日：2020-06-12

申请人： East China University of Science and Technology

发明人： LI, Honglin ,  ZHAO, Zhenjiang ,  WANG, Rui ,  SHEN, Yinchu ,  FU, Jianjun ,  XU, Yufang ,  QIAN, Xuhong ,  JIAO, Qian ,  LI, Shiliang

IPC分类号： A61P9/12 ,  A61K31/047 ,  C07C33/26 ,  C07C33/18 ,  C07C33/36 ,  C07C33/34 ,  C07D309/02

摘要： The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

公开(公告)号：EP3214079A1

公开(公告)日：2017-09-06

申请号：EP15855852.8

申请日：2015-10-30

申请人： East China University Of Science And Technology ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： LI, Honglin ,  JIANG, Hualiang ,  XU, Yufang ,  LI, Jia ,  ZHAO, Zhenjiang ,  LI, Jingya ,  XU, Hongling ,  LI, Shiliang

IPC分类号： C07D311/92 ,  C07D405/04 ,  C07D417/04 ,  C07D221/10 ,  C07D335/04 ,  A61K31/352 ,  A61K31/5377 ,  A61P3/00 ,  A61P3/10 ,  A61P7/10 ,  A61P29/00

摘要： The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor anda use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.

摘要翻译： 本发明涉及作为DPP-4抑制剂的六元环苯并衍生物及其用途。 具体地说，本发明涉及如式I所示的化合物，含有式I所示化合物的药物组合物以及该化合物在制备治疗DPP-4相关疾病或抑制DPP-4的药物中的用途 。