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公开(公告)号：EP1207797A1
公开(公告)日：2002-05-29
申请号：EP00955350.4
申请日：2000-08-02
申请人： Eastern Virginia Medical School of the Medical College of Hampton Roads , Old Dominion University Research Foundation
IPC分类号： A61B18/12
CPC分类号： A61B18/1206
摘要： A method for intracellular electro-manipulation is provided. The method includes applying one or more ultrashort electric field pulse to target cells. The ultrashort electric field pulses have sufficient amplitude and duration to modify subcellular structures in the target cells and do not exceed the breakdown field of the medium containing the target cells. The amplitude and duration of the ultrashort electric field pulse are typically insufficient to substantially alter permeability of the surface membranes of the target cells, e.g., by irreversibly disrupting the cell surface membranes. An apparatus for intracellular electro-manipulation is also provided. The apparatus includes a pulse generator capable of producing an ultrashort electric pulse output and a delivery system capable of directing the electric pulse output to target cells.
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公开(公告)号：EP1207797B1
公开(公告)日：2008-02-13
申请号：EP00955350.4
申请日：2000-08-02
申请人： Eastern Virginia Medical School of the Medical College of Hampton Roads , Old Dominion University Research Foundation
IPC分类号： A61B18/12
CPC分类号： A61B18/1206
摘要： A method for intracellular electro-manipulation is provided. The method includes applying one or more ultrashort electric field pulse to target cells. The ultrashort electric field pulses have sufficient amplitude and duration to modify subcellular structures in the target cells and do not exceed the breakdown field of the medium containing the target cells. The amplitude and duration of the ultrashort electric field pulse are typically insufficient to substantially alter permeability of the surface membranes of the target cells, e.g., by irreversibly disrupting the cell surface membranes. An apparatus for intracellular electro-manipulation is also provided. The apparatus includes a pulse generator capable of producing an ultrashort electric pulse output and a delivery system capable of directing the electric pulse output to target cells.
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