Inhibiting growth of leukemic cells by targeting HER-2 protein
    10.
    发明公开
    Inhibiting growth of leukemic cells by targeting HER-2 protein 失效
    Verfahren zur Wachstumshemmung vonLeukämischenZellen durch HER-2-Protein-Zeilen

    公开(公告)号:EP0711565A1

    公开(公告)日:1996-05-15

    申请号:EP95117465.5

    申请日:1995-11-07

    CPC分类号: C07K16/32 A61K39/39558

    摘要: The present invention identifies a subset of leukemic cells which express HER-2 protein on their cell surface. The invention features methods for inhibiting the growth of such cells and treating leukemia patients by targeting the HER-2 protein. The HER-2 protein is targeted using different techniques such as using anti-HER-2 agents which inhibit HER-2 protein activity and the growth of cells expressing HER-2, using anti-HER-2 agents which bind to HER-2 protein and kill cells expressing HER-2, and using HER-2 protein binding agents to selectively remove leukemic cells expressing HER-2 from normal hematopoietic cells.

    摘要翻译: 本发明鉴定了在其细胞表面上表达HER-2蛋白的白血病细胞亚群。 本发明的特征在于通过靶向HER-2蛋白来抑制这些细胞的生长和治疗白血病患者的方法。 使用不同的技术来靶向HER-2蛋白,例如使用结合HER-2蛋白的抗HER-2试剂使用抑制HER-2蛋白活性的抗HER-2试剂和表达HER-2的细胞的生长。 并杀死表达HER-2的细胞,并使用HER-2蛋白结合剂从正常造血细胞中选择性地除去表达HER-2的白血病细胞。