公开(公告)号：EP4026910A1

公开(公告)日：2022-07-13

申请号：EP20861118.6

申请日：2020-09-04

申请人： Edigene Inc.

发明人： YUAN, Pengfei ,  FANG, Riguo ,  JIN, Ming ,  ZHANG, Yongjian

IPC分类号： C12N15/90 ,  C12N5/10 ,  A61K35/28 ,  A61P35/00 ,  A61K38/17 ,  A61K48/00

摘要： Disclosed is a method for determining the suitability of a cell therapy for an individual. By means of using a bioinformatic method and an experimental analysis method for an unbiased potential off-target site, a potential off-target site of a genetically modified cell from an individual is predicted before administering a cell therapy to an individual, and the potential off-target site is monitored after administering, to the individual, the genetically modified cell from the individual to determine whether gene editing occurs at the potential off-target site and to evaluate the suitability of the therapy on the basis of the occurrence of a gene editing event.