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1.发明公开CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING gRNAS 有权CRISPR-ASSOZIIERTE VERFAHREN UND ZUSAMMENSETZUNGEN MIT REGELNDEN GRNAS
公开(公告)号：EP3066201A1
公开(公告)日：2016-09-14
申请号：EP14802772.5
申请日：2014-11-07
申请人： Editas Medicine, Inc. , The Broad Institute Inc. , Massachusetts Institute of Technology , The University of Iowa Research Foundation
发明人： GLUCKSMANN, Alexandra , PALESTRANT, Deborah , TARTAGLIA, Louis, Anthony , MATA-FINK, Jordi , CZECHOWICZ, Agnieszka, Dorota , BORISY, Alexis , ZHANG, Feng , DAVIDSON, Beverly , RODRIGUEZ, Edgardo
IPC分类号： C12N15/63
CPC分类号： C12N15/902 , C12N9/22 , C12N15/11 , C12N15/111 , C12N15/1137 , C12N15/63 , C12N2310/10 , C12N2310/20 , C12N2800/80
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
摘要翻译： 本文公开了可用于将有效载荷靶向或编辑靶核酸的方法和组合物，其中使用治疗性gRNA分子靶向，任选地灭活Cas9分子或Cas9分子/ gRNA复合物。
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公开(公告)号：EP3066201B1
公开(公告)日：2018-03-07
申请号：EP14802772.5
申请日：2014-11-07
申请人： Editas Medicine, Inc. , The Broad Institute Inc. , Massachusetts Institute of Technology , The University of Iowa Research Foundation
发明人： PALESTRANT, Deborah , MATA-FINK, Jordi , BORISY, Alexis , ZHANG, Feng , DAVIDSON, Beverly , RODRIGUEZ, Edgardo
IPC分类号： C12N15/63
CPC分类号： C12N15/902 , C12N9/22 , C12N15/11 , C12N15/111 , C12N15/1137 , C12N15/63 , C12N2310/10 , C12N2310/20 , C12N2800/80
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
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公开(公告)号：EP3363903A1
公开(公告)日：2018-08-22
申请号：EP18159400.3
申请日：2014-11-07
申请人： Editas Medicine, Inc. , The Broad Institute Inc. , Massachusetts Institute of Technology , The University of Iowa Research Foundation
发明人： PALESTRANT, Deborah , MATA-FINK, Jordi , BORISY, Alexis , ZHANG, Feng , DAVIDSON, Beverly , RODRIGUEZ, Edgardo
IPC分类号： C12N15/63
CPC分类号： C12N15/902 , C12N9/22 , C12N15/11 , C12N15/111 , C12N15/1137 , C12N15/63 , C12N2310/10 , C12N2310/20 , C12N2800/80
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
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公开(公告)号：EP4372090A2
公开(公告)日：2024-05-22
申请号：EP23219520.6
申请日：2014-11-07
申请人： Editas Medicine, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology , The University of Iowa Research Foundation
发明人： PALESTRANT, Deborah , MATA-FINK, Jordi , BORISY, Alexis , ZHANG, Feng , DAVIDSON, Beverly , RODRIGUEZ, Edgardo
IPC分类号： C12N15/63
CPC分类号： C12N15/63 , C12N15/111 , C12N15/1137 , C12N2310/1020130101 , C12N2310/2020170501 , C12N9/22
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
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公开(公告)号：EP4372090A3
公开(公告)日：2024-08-07
申请号：EP23219520.6
申请日：2014-11-07
申请人： Editas Medicine, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology , The University of Iowa Research Foundation
发明人： PALESTRANT, Deborah , MATA-FINK, Jordi , BORISY, Alexis , ZHANG, Feng , DAVIDSON, Beverly , RODRIGUEZ, Edgardo
CPC分类号： C12N15/63 , C12N15/111 , C12N15/1137 , C12N2310/1020130101 , C12N2310/2020170501 , C12N9/22
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
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