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    System for replacing a deficient native heart valve
    2.
    发明授权
    System for replacing a deficient native heart valve 有权
    系统zum Austauschen einer defektennatürlichenHerzklappe

    公开(公告)号：EP2399550B1

    公开(公告)日：2016-04-06

    申请号：EP11005559.7

    申请日：2002-10-11

    申请人： Edwards Lifesciences PVT, Inc.

    发明人： Spenser, Benjamin ,  Benichou, Netanel ,  Bash, Assaf ,  Zakai, Avraham

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2427 ,  A61F2/2403 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2421 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2463 ,  A61F2/82 ,  A61F2002/9522 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/0054 ,  A61F2230/0069 ,  A61F2250/001 ,  A61F2250/0098

    摘要： A prosthetic device for replacing a deficient native aortic valve is disclosed, comprising: - a collapsible and expandable support stent formed of a shape memory alloy, - the support stent comprising a proximal stent portion (310) configured to expand to a first diameter and - an distal stent portion (320) configured to expand to a second diameter, the first diameter being smaller than the second diameter for preventing deformation of the mitral valve by over expansion and for providing a difference between the support stent and the openings of the coronary arteries; and - a collapsible and expandable valve assembly formed of natural tissue, whereby the valve assembly is attached to the support stent circumferentially along an inlet and sutured to the support stent along commissures for supporting the valve leaflets; wherein the first diameter of the support stent is sized for engagement with leaflets of the native aortic valve and the second diameter of the support stent is sized for engagement with the inner wall of the ascending aorta and wherein the stent is sized to avoid a contact with the inner wall of a left ventricle when implanted.

    摘要翻译： 公开了一种用于替代缺乏的天然主动脉瓣的假体装置，包括： - 由形状记忆合金形成的可折叠和可扩张的支撑支架，所述支撑支架包括构造成扩张到第一直径的近端支架部分（310） 构造成扩张到第二直径的远端支架部分（320），所述第一直径小于所述第二直径，用于防止二尖瓣由于过度膨胀而变形，并且用于在支撑支架和冠状动脉的开口之间提供差异 ; 以及 - 由天然组织形成的可折叠且可膨胀的阀组件，由此所述阀组件沿着入口周向地附接到所述支撑支架，并且沿着用于支撑所述瓣叶的合并缝合到所述支撑支架; 其中所述支撑支架的所述第一直径的尺寸设定成与所述天然主动脉瓣的小叶接合，并且所述支撑支架的所述第二直径的尺寸被设计成与所述升主动脉的内壁接合，并且其中所述支架的尺寸设定成避免与 植入后左心室的内壁。

    SYSTEM FOR REPLACING A DEFICIENT NATIVE HEART VALVE
    4.
    发明公开
    SYSTEM FOR REPLACING A DEFICIENT NATIVE HEART VALVE 审中-公开
    系统ZUM AUSTAUSCHEN EINER DEFEKTENNATÜRLICHENHERZKLAPPE

    公开(公告)号：EP3042635A1

    公开(公告)日：2016-07-13

    申请号：EP16000181.4

    申请日：2002-10-11

    申请人： Edwards Lifesciences PVT, Inc.

    发明人： Spenser, Benjamin ,  Benichou, Netanel ,  Bash, Assaf ,  Zakai, Avraham

    IPC分类号： A61F2/24

    摘要： The present invention relates to a valve prosthesis suitable for implantation in body ducts, the device comprising:
    an expandable support frame;
    a valve assembly comprising a flexible conduit having an inlet and an outlet, the valve assembly made of pliant material forming a tricuspid valve assembly having three leaflets (430); and
    three pairs of parallel bars (480) for attaching the three leaflets to the support frame, wherein the leaflets (430) are held between the pairs of parallel bars.

    摘要翻译： 本发明涉及一种适于植入体内管道的瓣膜假体，该装置包括：可扩张的支撑框架; 阀组件，包括具有入口和出口的柔性导管，所述阀组件由柔顺材料制成，形成具有三个传单（430）的三尖瓣组件; 以及用于将三个传单附接到支撑框架的三对平行杆（480），其中所述传单（430）保持在所述对平行杆之间。

    SYSTEM FOR REPLACING A DEFICIENT NATIVE HEART VALVE
    9.
    发明公开
    SYSTEM FOR REPLACING A DEFICIENT NATIVE HEART VALVE 审中-公开

    公开(公告)号：EP3332740A1

    公开(公告)日：2018-06-13

    申请号：EP17199786.9

    申请日：2002-10-11

    申请人： Edwards Lifesciences PVT, Inc.

    发明人： Spenser, Benjamin ,  Benichou, Netanel ,  Bash, Assaf ,  Zakai, Avraham

    IPC分类号： A61F2/24

    摘要： A valve prosthesis device suitable for implantation in body ducts, the device comprising an expandable support frame adapted to be initially crimped in a narrow configuration suitable for catheterization through the body duct to a target location and configured to be expanded to an expanded configuration in the target location, the support frame being provided with a plurality of longitudinally rigid support beams of fixed length; and a valve assembly comprising a flexible conduit having an inlet and an outlet, made of pliant material attached to the support beams providing collapsible slack portions of the conduit at the outlet, whereby when flow is allowed to pass through the valve prosthesis device from the inlet to the outlet the valve assembly is kept in an open position, whereas a reverse flow is prevented as the collapsible slack portions of the valve assembly collapse inwardly providing blockage to the reverse flow, characterized in that the support beams are provided with bores, the valve assembly is stitched to the support beams with thread or fiber through the bores and the outlet is tapered with respect to the inlet and the support frame at the outlet is wider in diameter than the pliant material forming the outlet.

    Implantable prosthetic device
    10.
    发明授权
    Implantable prosthetic device 有权
    Implantierbare Prothesevorrichtung

    公开(公告)号：EP2399549B1

    公开(公告)日：2014-03-19

    申请号：EP11005557.1

    申请日：2002-10-11

    申请人： Edwards Lifesciences PVT, Inc.

    发明人： Spenser, Benjamin ,  Benichou, Netanel ,  Bash, Assaf ,  Zakai, Avraham

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2427 ,  A61F2/2403 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2421 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2463 ,  A61F2/82 ,  A61F2002/9522 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/0054 ,  A61F2230/0069 ,  A61F2250/001 ,  A61F2250/0098

    摘要： A prosthetic device for replacing a deficient native aortic valve is disclosed, comprising: - a collapsible and expandable support stent formed of a shape memory alloy, - the support stent comprising a proximal stent portion (310) configured to expand to a first diameter and - an distal stent portion (320) configured to expand to a second diameter, the first diameter being smaller than the second diameter for preventing deformation of the mitral valve by over expansion and for providing a difference between the support stent and the openings of the coronary arteries; and - a collapsible and expandable valve assembly formed of natural tissue, whereby the valve assembly is attached to the support stent circumferentially along an inlet and sutured to the support stent along commissures for supporting the valve leaflets; wherein the first diameter of the support stent is sized for engagement with leaflets of the native aortic valve and the second diameter of the support stent is sized for engagement with the inner wall of the ascending aorta and wherein the stent is sized to avoid a contact with the inner wall of a left ventricle when implanted.

    摘要翻译： 公开了一种用于替代缺乏的天然主动脉瓣的假体装置，包括： - 由形状记忆合金形成的可折叠和可扩张的支撑支架，所述支撑支架包括构造成扩张到第一直径的近端支架部分（310） 构造成扩张到第二直径的远端支架部分（320），所述第一直径小于所述第二直径，用于防止二尖瓣由于过度膨胀而变形，并且用于在支撑支架和冠状动脉的开口之间提供差异 ; 以及 - 由天然组织形成的可折叠且可膨胀的阀组件，由此所述阀组件沿着入口周向地附接到所述支撑支架，并且沿着用于支撑所述瓣叶的合并缝合到所述支撑支架; 其中所述支撑支架的所述第一直径的尺寸设定成与所述天然主动脉瓣的小叶接合，并且所述支撑支架的所述第二直径的尺寸被设计成与所述升主动脉的内壁接合，并且其中所述支架的尺寸设定成避免与 植入后左心室的内壁。