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1.发明授权NOVEL 2,3-BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 有权“NEW 2,3-苯并二氮杂衍生物及其药物组合物含有这些化合物作为活性含有”
公开(公告)号：EP1351942B1
公开(公告)日：2004-07-21
申请号：EP01271364.0
申请日：2001-12-19
发明人： LING, István , BARKOCZY, Jozsef , SIMIG, Gyula , GREFF, Zoltán , RATKAI, Zoltán , SZABO, Géza , VEGH, Miklos , GIGLER, Gábor , SZENASI, Gábor , MARTONNE MARKO, Bernadett , LEVAY, György , HARSING, Lászlo, Gábor
IPC分类号： C07D243/02 , A61K31/551 , A61P25/00
CPC分类号： C07D243/02
摘要： The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds have antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a C1-4 alkyl group or a group of the formula -NR1R2, wherein R?1 and R2¿ represent, independently, a hydrogen atom, a C¿1-4? alkyl group, a C1-4 alkoxy group or a C?3-6¿ cycloalkyl group.
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2.发明公开NOVEL 2,3-BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 有权“NEW 2,3-苯并二氮杂衍生物及其药物组合物含有这些化合物作为活性含有”
公开(公告)号：EP1351942A1
公开(公告)日：2003-10-15
申请号：EP01271364.0
申请日：2001-12-19
发明人： LING, István , BARKOCZY, Jozsef , SIMIG, Gyula , GREFF, Zoltán , RATKAI, Zoltán , SZABO, Géza , VEGH, Miklos , GIGLER, Gábor , SZENASI, Gábor , MARTONNE MARKO, Bernadett , LEVAY, György , HARSING, Lászlo, Gábor
IPC分类号： C07D243/02 , A61K31/551 , A61P25/00
CPC分类号： C07D243/02
摘要： The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds have antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a C1-4 alkyl group or a group of the formula -NR1R2, wherein R?1 and R2¿ represent, independently, a hydrogen atom, a C¿1-4? alkyl group, a C1-4 alkoxy group or a C?3-6¿ cycloalkyl group.
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3.发明公开NEW PIPERIDINYL-ALKYLAMINO-PYRIDAZINONE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS 有权新的哌啶基 - 烷基氨基 - 哒嗪酮衍生物，其制备方法以及包含所述化合物的药物组合物
公开(公告)号：EP1501823A1
公开(公告)日：2005-02-02
申请号：EP02807294.0
申请日：2002-12-28
发明人： BARKOCZY, Jozsef , GACSALYI, István , HARSING, Lászlo, Gábor , KOTAY NAGY, Péter; , LEVAY, György , SCHMIDT, Eva , SIMIG, Gyula
IPC分类号： C07D401/12 , A61K31/50 , A61P25/22
CPC分类号： C07D401/06
摘要： The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C1-4-alkyl; one of X and Y stands for hydrogen and the other represents a group of the general Formula (II) Hal stands for halogen; and n is 1 or 2) and pharmaceutically acceptable acid addition salts thereof a process for the preparation thereof and pharmaceutical compositions comprising said compounds. The compounds of the general Formula I exhibit anxiolytic effect and are useful in the treatment of anxiety.
摘要翻译： 本发明涉及通式（I）的新的哌啶基 - 烷基氨基 - 哒嗪酮衍生物（其中R是氢或C 1-4 - 烷基; X和Y之一代表氢，另一个代表通式（II） ）Hal代表卤素; n是1或2）及其药学上可接受的酸加成盐，其制备方法和包含所述化合物的药物组合物。 通式I的化合物表现出抗焦虑作用并可用于治疗焦虑症。
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4.发明公开PHARMACEUTICAL COMPOSITION COMPRISING DERAMCICLANE FOR THE TREATMENT OF THE DECLINE AND/OR DAMAGE OF COGNITIVE FUNCTIONS 有权德伦环烷，药物组合物，异径认知功能和/或IT损坏的治疗
公开(公告)号：EP1408940A2
公开(公告)日：2004-04-21
申请号：EP02745700.1
申请日：2002-07-18
IPC分类号： A61K31/135 , A61P25/16 , A61P25/28 , A61P25/14
CPC分类号： A61K31/135
摘要： The compounds of the general Formula (I) (wherein R stands for hydrogen or methyl) can be used for the treatment or prophylaxis of diseases characterized either by the decline and/or damage of cognitive functions, or mental disability accompanying other diseases. As compound of the general Formula I preferably -(1R,2S,4R)-(-)-2-(2-dimethylaminoethoxy)-2-phenyl-1,7,7-trimethylbicyclo[2.2.1]heptane-fumarate can be used.
摘要翻译： 通式（I）（worin R代表氢或甲基）的化合物可用于通过下降和/或认知功能损害，或精神障碍伴随其他疾病，其特征要么的疾病的治疗或预防。 作为通式I的化合物优选 - （1R，2S，4R） - （ - ） - 2-（2-二甲基氨基乙氧基）-2-苯基 - 1,7,7-三甲基双环[2.2.1]庚烷富马酸盐可以是 使用。
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5.发明授权NEW PIPERIDINYL-ALKYLAMINO-PYRIDAZINONE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS 有权新PIPERIDINYLALKYLAMINOPYRIDAZINONDERIVATE，进程及其制备方法和药物组合物含有这些化合物
公开(公告)号：EP1501823B1
公开(公告)日：2005-12-07
申请号：EP02807294.0
申请日：2002-12-28
发明人： BARKOCZY, Jozsef , GACSALYI, István , HARSING, Lászlo, Gábor , KOTAY NAGY, Péter; , LEVAY, György , SCHMIDT, Eva , SIMIG, Gyula
IPC分类号： C07D401/12 , A61K31/50 , A61P25/22
CPC分类号： C07D401/06
摘要： The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C1-4-alkyl; one of X and Y stands for hydrogen and the other represents a group of the general Formula (II) Hal stands for halogen; and n is 1 or 2) and pharmaceutically acceptable acid addition salts thereof a process for the preparation thereof and pharmaceutical compositions comprising said compounds. The compounds of the general Formula I exhibit anxiolytic effect and are useful in the treatment of anxiety.
摘要翻译： 本发明涉及通式（I）的新的哌啶基烷基氨基哒嗪酮衍生物（worin R是氢或C 1-4 烷基; X和Y之一代表氢，而另一个darstellt 的基团，通式（II）的Hal代表卤素;且n为1或2）及其药学可接受的酸加成其制备和药物组合物包括所述化合物的方法的盐。 通式I的化合物表现出抗焦虑作用，并且在治疗焦虑症是有用的。
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