公开(公告)号：EP1463719A2

公开(公告)日：2004-10-06

申请号：EP03715921.7

申请日：2003-01-08

申请人： Eisai Co., Ltd

发明人： AGOULNIK, Sergei ,  AKASAKA, Kozo ,  FANG, Frank ,  HARMANGE, Jean-Christophe ,  HAWKINS, Lynn ,  JIANG, Yimin ,  JOHANNES, Charles ,  LI, Xiang-Yi ,  MCGUINNESS, Pamela ,  MURPHY, Erin, A. ,  SCHILLER, Shawn ,  VERMEULEN, Mary ,  WU, Jiayi

IPC分类号： C07D303/36 ,  C07D405/12 ,  C07D407/12 ,  C07D209/48 ,  A61K31/336 ,  A61K31/16 ,  A61K38/05 ,  A61P35/00 ,  A61P29/00 ,  C07K5/06 ,  C07C235/08 ,  C07C235/06 ,  C07C233/76 ,  C07C235/82 ,  C07C271/22 ,  C07F5/02 ,  C07F9/655 ,  A61K31/665 ,  A61K31/69

CPC分类号： C07D209/48 ,  A61K38/00 ,  C07D303/36 ,  C07D405/12 ,  C07D407/12 ,  C07F5/025 ,  C07F9/65502 ,  C07K5/06139

摘要： The present invention provides compounds having formula (I) : wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.