公开(公告)号：EP1474425A1

公开(公告)日：2004-11-10

申请号：EP03729359.4

申请日：2003-01-07

申请人： Eisai Co. Ltd.

发明人： DAUN, Jane ,  DAVIS, Heather, A. ,  GUSOVSKY, Fabian ,  HISHINUMA, Ieharu ,  JIANG, Yimin ,  KANEKO, Toshihiko ,  KIKUCHI, Kouichi ,  KOBAYASHI, Seiichi ,  LESCARBEAU, Andre ,  LI, Xiang-Li ,  MURAMOTO, Kenzo ,  OHI, Norihito ,  PESANT, Marc ,  SELETSKY, Boris, M. ,  SOEJIMA, Motohiko ,  YAO, Ye ,  YOKOHAMA, Hiromitsu ,  ZHAO, Janet, Y. ,  ZHENG, Wanjun ,  TREMBLAY, Lynda

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： A61K31/437 ,  C07D471/04

摘要： The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.