公开(公告)号：EP1380653B1

公开(公告)日：2007-10-10

申请号：EP02705339.6

申请日：2002-03-19

申请人： Eisai R&D Management Co., Ltd.

发明人： ATSUMI, Tatsuya ,  KOIKE, Takao

IPC分类号： C12P21/08 ,  C12N15/00 ,  C12N5/10 ,  C07K16/36 ,  G01N33/53 ,  G01N33/577 ,  G01N33/86

CPC分类号： C07K16/40 ,  C07K16/36 ,  C07K2317/32 ,  G01N33/577 ,  G01N33/86

摘要： A monoclonal antibody which reacts with prothrombin forming a complex with phosphatidylserine but not with prothrombin forming no complex with phosphatidylserine; and a method of assaying an activity of a test plasma of inhibiting blood coagulation which involves: (1) the step of assaying the inhibitory activity of the test plasma on blood coagulation reaction and its inhibitory activity on the blood coagulation reaction; and (2) the step of comparing the inhibitory activity of the test plasma with the inhibitory activity of the antibody.