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公开(公告)号：EP4259798A1
公开(公告)日：2023-10-18
申请号：EP21840305.3
申请日：2021-12-10
发明人： FANG, Francis, G. , KIM, Dae-Shik , CHOI, Hyeong Wook , TAKAHASHI, Yoshinori , KIKUTA, Kenji , KAWASHIMA, Hikaru , ITANO, Wataru , KUROKAWA, Toshiki , HOSHIKAWA, Tamaki , SHAN, Mingde , WANG, John
IPC分类号： C12N15/113 , C07H21/04
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2.发明公开METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES 有权方法和化合物合成简明AMINODIHYDROTHIAZINDERIVATEN的
公开(公告)号：EP2665716A1
公开(公告)日：2013-11-27
申请号：EP12702690.4
申请日：2012-01-20
发明人： MITASEV, Branko , KIM, Dae-Shik , ZHANG, Huiming , SCHNADERBECK, Matthew J. , FARTHING, Christopher N. , YOSHIZAWA, Kazuhiro
IPC分类号： C07D307/22 , C07D498/04 , C07D513/04
CPC分类号： C07D307/22 , C07D498/04 , C07D513/04
摘要： Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.
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公开(公告)号：EP3801561A1
公开(公告)日：2021-04-14
申请号：EP19734956.6
申请日：2019-05-31
发明人： KIM, Dae-Shik , FANG, Frank , ENDO, Atsushi , CHOI, Hyeong-Wook , HAO, Ming-Hong , BAO, Xingfeng , HUANG, Kuan-Chun
IPC分类号： A61K31/7084 , A61P35/00
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4.发明公开
公开(公告)号：EP3478691A1
公开(公告)日：2019-05-08
申请号：EP17821400.3
申请日：2017-06-30
IPC分类号： C07D493/22 , C07D321/00
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5.发明公开
公开(公告)号：EP3689881A1
公开(公告)日：2020-08-05
申请号：EP20156829.2
申请日：2014-11-04
IPC分类号： C07D493/22 , C07D307/28 , C07C6/02 , C07F9/40
摘要： The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
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公开(公告)号：EP3582853A1
公开(公告)日：2019-12-25
申请号：EP18708032.0
申请日：2018-02-17
发明人： KIM, Dae-Shik , FANG, Frank , ENDO, Atsushi , CHOI, Hyeong-Wook , HAO, Ming-Hong , BAO, Xingfeng , HUANG, Kuan-Chun
IPC分类号： A61P31/04 , A61K31/7084 , C07F9/6527 , C07F9/6574 , C07H19/213 , A61P37/04
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7.发明公开MACROCYCLIZATION REACTIONS AND INTERMEDIATES AND OTHER FRAGMENTS USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES 审中-公开MACROCYCL化反应和中间体及其他碎片用于合成HALICHONDRIN MACROLIDES
公开(公告)号：EP3292130A1
公开(公告)日：2018-03-14
申请号：EP16790247.7
申请日：2016-05-09
IPC分类号： C07D491/22 , C07D493/22 , A61K31/55
摘要： The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.
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公开(公告)号：EP3292130B1
公开(公告)日：2020-09-30
申请号：EP16790247.7
申请日：2016-05-09
IPC分类号： C07D491/22 , C07D493/22 , A61K31/55
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9.发明授权
公开(公告)号：EP3066102B1
公开(公告)日：2020-02-26
申请号：EP14858240.6
申请日：2014-11-04
IPC分类号： C07D493/22 , C07D307/28 , C07C6/02
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公开(公告)号：EP3582854A1
公开(公告)日：2019-12-25
申请号：EP18709835.5
申请日：2018-02-17
发明人： KIM, Dae-Shik , FANG, Frank , ENDO, Atsushi , CHOI, Hyeong-Wook , HAO, Ming-Hong , BAO, Xingfeng , HUANG, Kuan-Chun
IPC分类号： A61P31/04 , A61K31/7084 , C07F9/6527 , C07F9/6574 , C07H19/213 , A61P37/04 , C07F9/6536
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