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公开(公告)号：EP2726465A1
公开(公告)日：2014-05-07
申请号：EP12726282.2
申请日：2012-05-21
发明人： AUBELE, Danielle, L. , GAROFALO, Albert, W. , BOWERS, Simeon , TRUONG, Anh, P. , YE, Xiaocong, Michael , FRANZINI, Maurizio , ADLER, Marc , NEITZ, R., Jeffrey , PROBST, Gary
IPC分类号： C07D237/28 , C07D403/04 , C07D417/04 , C07D401/04 , C07D403/10 , A61K31/502 , C07D401/10 , C07D405/04 , A61P25/16 , C07D401/12 , C07D405/10 , A61P25/28 , C07D401/14 , C07D405/12 , A61P37/00
CPC分类号： C07D237/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D413/10 , C07D417/04
摘要： The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式I结构的化合物：（I）或其盐或溶剂化物，其中R1，R2，R3和R4如本文所定义。 本发明进一步提供包含本发明化合物的药物组合物，以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：EP2346863A2
公开(公告)日：2011-07-27
申请号：EP09792258.7
申请日：2009-09-04
发明人： KONRADI, Andrei, W. , YE, Xiaocong, Michael , BOWERS, Simeon , GAROFALO, Albert, W. , AUBELE, Danielle, L. , DRESSEN, Darren , NG, Raymond , PROBST, Gary , SEMKO, Christopher, M. , SUN, Minghua , TRUONG, Anh, P. , DAPPEN, Michael, S.
IPC分类号： C07D451/00 , A61K31/438 , A61K31/46 , A61P25/28
CPC分类号： C07D451/14 , C07D451/00
摘要： The current invention provides compounds having a structure according to Formulae (1), (2), (3), and (4): wherein the A-ring, B-ring, C-ring, m, n, R
25 , R
50 , and R
51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae (1), (2), (3), and (4), as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae (1), (2), (3), and (4).-
公开(公告)号：EP2516441A1
公开(公告)日：2012-10-31
申请号：EP10798439.5
申请日：2010-12-21
发明人： GALEMMO, Robert, A., Jr. , ARTIS, Dean Richard , YE, Xiaocong Michael , AUBELE, Danielle, L. , TRUONG, Anh, P. , BOWERS, Simeon , HOM, Roy, K. , ZHU, Yong-Liang , NEITZ, R., Jeffrey , SEALY, Jennifer , ADLER, Marc , BEROZA, Paul , ANDERSON, John, P.
IPC分类号： C07D475/04 , C07D475/12 , A61K31/4985 , A61P25/00
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E1, E2, R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有根据式（I）的结构的化合物或其盐或溶剂合物，其中环A，E1，E2，R1，R2，R3和R4如本文所定义。 本发明进一步提供了包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如用于治疗和预防各种病症如帕金森氏病。
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4.发明公开
公开(公告)号：EP1916985A2
公开(公告)日：2008-05-07
申请号：EP06813596.1
申请日：2006-08-18
发明人： BOWERS, Simeon , GAROFALO, Albert, W. , HOM, Roy, K. , KONRADI, Andrei, W. , MATTSON, Matthew, N. , NEITZEL, Martin, L. , SEMKO, Christopher, M. , TRUONG, Anh, P. , WU, Jing , XU, Ying-zi
IPC分类号： A61K8/00
CPC分类号： C07D451/14 , C07D471/08 , C07D471/18 , C07D471/22 , C07D498/08
摘要： The invention provides N-cyclic sulfonamido compounds and salts of Formula (I): wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula (I) are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula (I).
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公开(公告)号：EP2516441B1
公开(公告)日：2015-01-21
申请号：EP10798439.5
申请日：2010-12-21
发明人： GALEMMO, Robert, A., Jr. , ARTIS, Dean Richard , YE, Xiaocong Michael , AUBELE, Danielle, L. , TRUONG, Anh, P. , BOWERS, Simeon , HOM, Roy, K. , ZHU, Yong-Liang , NEITZ, R., Jeffrey , SEALY, Jennifer , ADLER, Marc , BEROZA, Paul , ANDERSON, John, P.
IPC分类号： C07D475/04 , C07D475/12 , A61K31/4985 , A61P25/00
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
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