公开(公告)号：EP2424841A1

公开(公告)日：2012-03-07

申请号：EP10719684.2

申请日：2010-04-27

申请人： Elan Pharmaceuticals Inc.

发明人： XU, Ying-Zi ,  YUAN, Shendong ,  WONE, David ,  KONRADI, Andrei

IPC分类号： C07D213/02 ,  C07D401/12 ,  A61K31/4412 ,  A61P37/00

CPC分类号： C07D213/82 ,  C07D401/14 ,  C07D405/14 ,  G01N33/68

摘要： The present invention provides compounds that are alpha4 integrin antagonists having a structure according to the following formula (I) or a tautomer, mixture of tautomers, salt or solvate thereof, wherein Cy, ring A, m, n, p, R
1 , R
2 , R
3 , R
4 , R
5 and R
6 are defined in the specification. The invention further provides pharmaceutical compositions including the compounds of the invention as well as methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various conditions and disorders, such as Crohn's disease and ulcerative colitis.

摘要翻译： 本发明提供了具有根据下式（I）的结构的α4整联蛋白拮抗剂或其互变异构体，互变异构体混合物，盐或溶剂化物的化合物，其中Cy，环A，m，n，p，R 1，R 2，R 3，R 4，R 5和R 6在说明书中定义。 本发明进一步提供了包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如用于治疗和预防各种病症和病症，如克罗恩氏病和溃疡性结肠炎。

公开(公告)号：EP2827857A1

公开(公告)日：2015-01-28

申请号：EP13764741.8

申请日：2013-03-20

申请人： Elan Pharmaceuticals Inc. ,  Xu, Ying-Zi ,  Artis, Dean R. ,  Bowers, Simeon ,  Hom, Roy K. ,  Sham, Hing L. ,  Yuan, Shendong

发明人： XU, Ying-Zi ,  ARTIS, Dean, R. ,  BOWERS, Simeon ,  HOM, Roy, K. ,  SHAM, Hing, L. ,  YUAN, Shendong

IPC分类号： A61K31/357 ,  A61K31/547

CPC分类号： C07D513/10 ,  C07D265/12 ,  C07D265/18 ,  C07D279/08 ,  C07D279/16 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/10

摘要： Compounds are provided having a structure according to Formula (I): wherein A
1 , A
2 , A
3 , Y, R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , m, n and p are defined herein. Further provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.