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公开(公告)号：EP1735278A1
公开(公告)日：2006-12-27
申请号：EP05730691.2
申请日：2005-03-25
发明人： BEAVERS, Lisa, Selsam , FINLEY, Don, Richard , FINN, Terry, Patrick Eli Lilly and Company , GADSKI, Robert, Alan , HIPSKIND, Philip, Arthur , HORNBACK, William, Joseph , JESUDASON, Cynthia, Darshini , PICKARD, Richard, Todd , TAKAKUWA, Takako , VAUGHT, Grant, Mathews
IPC分类号： C07D207/09 , C07D401/10 , C07D413/10 , C07D403/10 , C07D405/10 , A61K31/00 , A61K31/4025 , A61P25/00 , A61P3/04
CPC分类号： C07D207/09 , C07D401/10 , C07D403/10 , C07D405/10 , C07D413/10 , C07D471/04
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases
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公开(公告)号：EP2451793B1
公开(公告)日：2016-11-02
申请号：EP10731890.9
申请日：2010-07-06
发明人： AUDIA, James, Edmund , MERGOTT, Dustin, James , SHI, Chongsheng, Eric , VAUGHT, Grant, Mathews , WATSON, Brian, Morgan , WINNEROSKI, Leonard, Larry, Jr.
IPC分类号： C07D279/08 , C07D498/04 , C07D513/02
CPC分类号： C07D513/02 , C07D279/08 , C07D498/04
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公开(公告)号：EP1904442A1
公开(公告)日：2008-04-02
申请号：EP06774260.1
申请日：2006-06-28
发明人： BEAVERS, Lisa, Selsam , FINLEY, Don, Richard , GADSKI, Robert, Alan , HIPSKIND, Philip, Arthur , HORNBACK, William, Joseph , JESUDASON, Cynthia, Darshini , PICKARD, Richard, Todd , TAKAKUWA, Takako , VAUGHT, Grant, Mathews
IPC分类号： C07D207/09 , C07D403/12 , C07D401/12 , A61K31/4025 , A61P3/04 , A61P25/28
CPC分类号： C07D207/09 , C07D401/12 , C07D403/12
摘要： The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. (Formula I)
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公开(公告)号：EP2451793A1
公开(公告)日：2012-05-16
申请号：EP10731890.9
申请日：2010-07-06
发明人： AUDIA, James, Edmund , MERGOTT, Dustin, James , SHI, Chongsheng, Eric , VAUGHT, Grant, Mathews , WATSON, Brian, Morgan , WINNEROSKI, Leonard, Larry, Jr.
IPC分类号： C07D279/08 , C07D498/04 , C07D513/02
CPC分类号： C07D513/02 , C07D279/08 , C07D498/04
摘要： The present invention provides BACE inhibitors of Formula I: methods for their use, intermediates, and methods for their preparation.
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公开(公告)号：EP1904442B1
公开(公告)日：2011-09-07
申请号：EP06774260.1
申请日：2006-06-28
发明人： BEAVERS, Lisa, Selsam , FINLEY, Don, Richard , GADSKI, Robert, Alan , HIPSKIND, Philip, Arthur , HORNBACK, William, Joseph , JESUDASON, Cynthia, Darshini , PICKARD, Richard, Todd , TAKAKUWA, Takako , VAUGHT, Grant, Mathews
IPC分类号： C07D207/09 , C07D403/12 , C07D401/12 , A61K31/4025 , A61P3/04 , A61P25/28
CPC分类号： C07D207/09 , C07D401/12 , C07D403/12
摘要： The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. (Formula I)
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公开(公告)号：EP1735278B1
公开(公告)日：2010-01-06
申请号：EP05730691.2
申请日：2005-03-25
发明人： BEAVERS, Lisa, Selsam , FINLEY, Don, Richard , FINN, Terry, Patrick Eli Lilly and Company , GADSKI, Robert, Alan , HIPSKIND, Philip, Arthur , HORNBACK, William, Joseph , JESUDASON, Cynthia, Darshini , PICKARD, Richard, Todd , TAKAKUWA, Takako , VAUGHT, Grant, Mathews
IPC分类号： C07D207/09 , C07D401/10 , C07D413/10 , C07D403/10 , C07D405/10 , A61K31/00 , A61K31/4025 , A61P25/00 , A61P3/04
CPC分类号： C07D207/09 , C07D401/10 , C07D403/10 , C07D405/10 , C07D413/10 , C07D471/04
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases
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