公开(公告)号：EP0696192A1

公开(公告)日：1996-02-14

申请号：EP94915419.0

申请日：1994-04-22

申请人： Emisphere Technologies, Inc.

发明人： MILSTEIN, Sam J. ,  BARANTSEVITCH, Evgueni Apartment 2B

IPC分类号： A61K9 ,  A61K47

CPC分类号： A61K9/1658

摘要： Modified hydrolyzed vegetable protein microspheres and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. Figure 1 illustrates levels of glucose detected in rat serum taken from rats orally administered microsphere encapsulated insulin or raw (unencapsulated) insulin as described in example 4. Figure 2 illustrates rat serum calcium levels after oral administration of calcitonin and calcitonin encapsulated in the vegetable protein microsphere of the present invention as described in example 5. Figure 3 illustrates an HPLC trace of the hydrolyzed vegetable protein before modification. Figure 4 illustrates the change in the hydrolyzed vegetable protein after modification with benzene sulfonyl chloride in an HPLC trace.