公开(公告)号：EP3915560A1

公开(公告)日：2021-12-01

申请号：EP21169365.0

申请日：2015-06-25

申请人： Emory University

发明人： RESSLER, Kerry L. ,  GALI, Raul, Andero

IPC分类号： A61K31/4545 ,  A61K31/444 ,  A61K31/5377 ,  A61K31/539 ,  A61P25/00 ,  A61K45/06 ,  A61K31/135 ,  A61K31/138 ,  A61K31/165 ,  A61K31/197 ,  A61K31/343 ,  A61K31/4525 ,  A61K31/4985 ,  A61K31/55 ,  A61K31/573

摘要： This disclosure relates to managing conditioned fear and conditions induced by experiencing or witnessing an extreme traumatic event using neurokinin receptor antagonists. In certain embodiments, the disclosure relates to methods of treating or preventing conditioned fear comprising administering an effective about neurokinin 3 receptor antagonist to a subject in need thereof. In certain embodiments, the subject is diagnosed with Post-Traumatic Stress Disorder. In certain embodiments, the neurokinin 3 receptor antagonist is (R)-N-{{3-[1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1-yl}-4-phenylpiperidin-4-yl}-N-methylacetamine or salts thereof.