公开(公告)号：EP4325111A3

公开(公告)日：2024-05-01

申请号：EP23219278.1

申请日：2017-07-12

申请人： Emulate, Inc.

发明人： Levner, Daniel ,  Sliz, Josiah Daniel ,  Hinojosa, Christopher David ,  Gomes, Joshua ,  Jang, Kyung Jin

IPC分类号： B01L3/00 ,  B81B3/00 ,  C12M1/00 ,  C12M1/36 ,  C12M3/06 ,  F17D1/08 ,  F17D1/20

CPC分类号： B01L2200/02720130101 ,  B01L2300/068120130101 ,  B01L2300/088720130101 ,  B01L2400/048720130101 ,  B01L3/502715 ,  B01L3/502723 ,  B01L2200/068420130101 ,  B01L2300/081620130101 ,  B01L2300/1220130101 ,  B01L2300/1420130101 ,  C12M23/16 ,  C12M29/20 ,  B01L2200/02520130101 ,  B01L2300/1020130101

摘要： Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.

公开(公告)号：EP4325111A2

公开(公告)日：2024-02-21

申请号：EP23219278.1

申请日：2017-07-12

申请人： Emulate, Inc.

发明人： Levner, Daniel ,  Sliz, Josiah Daniel ,  Hinojosa, Christopher David ,  Gomes, Joshua ,  Jang, Kyung Jin

IPC分类号： F17D1/20

摘要： Methods of removing bubbles from a microfluidic device are described where the flow is not stopped. Methods are described that combine pressure and flow to remove bubbles from a microfluidic device. Bubbles can be removed even where the device is made of a polymer that is largely gas impermeable.

公开(公告)号：EP4026616A1

公开(公告)日：2022-07-13

申请号：EP22157303.3

申请日：2016-08-26

申请人： Emulate, Inc.

发明人： Levner, Daniel ,  Sliz, Josiah Daniel ,  Hinojosa, Christopher David ,  Thompson II, Guy Robert ,  van Ruijven, Petrus Martinus ,  Solomon, Matthew Daniel ,  Potzner, Christian Alexander ,  Tuohy, Patrick Sean ,  Wen, Norman ,  Gomes, Joshua ,  Freake, Jacob ,  Doug, Doug

IPC分类号： B01L3/00 ,  C12M3/00 ,  C12M3/06 ,  C12M1/00 ,  C12M1/42 ,  C12M1/34 ,  C12M1/36

摘要： A culture module (30) putting a microfluidic device in fluidic communication with a perfusion manifold (50) assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body and that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir.

公开(公告)号：EP3656844A1

公开(公告)日：2020-05-27

申请号：EP19214561.3

申请日：2016-08-26

申请人： Emulate, Inc.

发明人： Levner, Daniel ,  Sliz, Josiah Daniel ,  Hinojosa, Christopher David ,  Thompson II, Guy Robert ,  Martinus van Ruijven, Petrus ,  Solomon, Matthew Daniel ,  Potzner, Christian Alexander ,  Tuohy, Patrick Sean ,  Wen, Norman ,  Gomes, Joshua ,  Freake, Jacob ,  Sabin, Doug

IPC分类号： C12M1/34 ,  B01L3/00 ,  C12M1/00 ,  C12M3/00 ,  G01N33/00 ,  G01N33/50 ,  B01L9/00 ,  C12M3/06 ,  C12M1/36 ,  C12M1/42

摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports (2) of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.