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公开(公告)号：EP3205724A1
公开(公告)日：2017-08-16
申请号：EP17153863.0
申请日：2008-03-26
IPC分类号： C12N15/11 , A61K48/00 , C12N15/113 , C12N15/88
CPC分类号： C12N15/111 , A61K48/0008 , A61K48/0091 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N15/88 , C12N2310/11 , C12N2310/12 , C12N2310/13 , C12N2310/14 , C12N2320/32 , C12N2810/855 , C12N2810/859 , C12Y207/11021
摘要： Intact, bacterially-derived minicells can safely introduce therapeutically effective amounts of plasmid-free functional nucleic acid to target mammalian cells. To this end, functional nucleic acid can be packaged into intact minicells directly, without resort to expression constructs, the expression machinery of the host cell, harsh chemicals or electroporation.
摘要翻译： 完整的细菌衍生的小细胞可以将治疗有效量的无质粒功能性核酸安全地导入靶哺乳动物细胞。 为此，功能性核酸可以直接包装到完整的小细胞中，而不需要表达构建体，宿主细胞的表达机制，苛刻的化学物质或电穿孔。
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公开(公告)号：EP3564372A1
公开(公告)日：2019-11-06
申请号：EP19172998.7
申请日：2008-03-26
IPC分类号： C12N15/11 , A61K48/00 , C12N15/113 , C12N15/88
摘要： Intact, bacterially-derived minicells can safely introduce therapeutically effective amounts of plasmid-free functional nucleic acid to target mammalian cells. To this end, functional nucleic acid can be packaged into intact minicells directly, without resort to expression constructs, the expression machinery of the host cell, harsh chemicals or electroporation.
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公开(公告)号：EP3205724B1
公开(公告)日：2019-05-08
申请号：EP17153863.0
申请日：2008-03-26
IPC分类号： C12N15/11 , A61K48/00 , C12N15/113 , C12N15/88
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