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公开(公告)号：EP3875082A1
公开(公告)日：2021-09-08
申请号：EP21150716.5
申请日：2013-11-14
申请人： Endocyte, Inc.
发明人： VLAHOV, Iontcho Radoslavov , REDDY, Joseph Anand , BLOOMFIELD, Alicia , DORTON, Ryan , NELSON, Melissa , VETZEL, Marilynn , LEAMON, Christopher Paul
IPC分类号： A61K31/17 , A61K49/00 , A61K49/10 , A61P35/00 , A61K38/05 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/54 , A61K47/64 , C07K5/02 , C07K5/072 , C07K5/11 , A61P13/08 , A61P13/10
摘要： The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using a conjugate of the general formula B-L-(D)n as further defined in the claims.
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公开(公告)号：EP3334447A1
公开(公告)日：2018-06-20
申请号：EP16837521.0
申请日：2016-08-10
申请人： Endocyte, Inc.
发明人： PARHAM, Garth L. , NELSON, Melissa , VETZEL, Marilynn , DIRCKSEN, Christina M. , REDDY, Joseph Anand , LEAMON, Christopher Paul , VLAHOV, Iontcho Radoslavov
IPC分类号： A61K38/03 , A61K38/14 , C07D243/12
CPC分类号： A61K47/64 , A61K31/5513 , A61K38/03 , A61K38/07 , A61K38/14 , A61K49/00 , A61K51/088 , A61P35/00 , C07D209/20 , C07D243/12 , C07D405/14 , C07D417/14
摘要： The disclosure provided herein pertains to CCK2R-drug conjugates. In particular, the disclosure pertains to CCK2R-drug conjugates that target the delivery of drugs to a mammalian recipient. Also described are methods of making and using CCK2R-drug conjugates.
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公开(公告)号：EP3858341A1
公开(公告)日：2021-08-04
申请号：EP21150714.0
申请日：2013-11-14
申请人： Endocyte, Inc.
发明人： VLAHOV, Iontcho Radoslavov , REDDY, Joseph Anand , BLOOMFIELD, Alicia , DORTON, Ryan , NELSON, Melissa , VETZEL, Marilynn , LEAMON, Christopher Paul
IPC分类号： A61K31/17 , A61K49/00 , A61K49/10 , A61P35/00 , A61K38/05 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/54 , A61K47/64 , C07K5/02 , C07K5/072 , C07K5/11
摘要： The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.
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公开(公告)号：EP3197502A1
公开(公告)日：2017-08-02
申请号：EP15843633.7
申请日：2015-09-24
申请人： Endocyte, Inc.
发明人： LEAMON, Christopher Paul , REDDY, Joseph Anand , NGUYEN, Binh , BLOOMFIELD, Alicia , NELSON, Melissa , DORTON, Ryan
CPC分类号： A61K38/05 , A61K31/519 , A61K47/48338 , A61K47/551 , A61K47/645 , A61K51/0459 , A61K51/088
摘要： The invention described herein pertains to drug delivery conjugates for targeted therapy. The invention described herein relates to methods of treating folate receptor-expressing cancers with a folate-tubulysin conjugate. The invention described herein also relates to methods of treating folate-expressing cancers with a folate tubulysin conjugate in patients where stable disease results after treatment with the folate-tubulysin conjugate.
摘要翻译： 本文所述的发明涉及用于靶向治疗的药物递送缀合物。 本文所述的发明涉及用叶酸 - 微管溶素结合物治疗表达叶酸受体的癌症的方法。 本文所述的发明还涉及在用叶酸 - 微管溶素结合物治疗后导致稳定疾病的患者中用叶酸盐微管蛋白结合物治疗表达叶酸的癌症的方法。
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5.发明公开
公开(公告)号：EP2919774A1
公开(公告)日：2015-09-23
申请号：EP13855243.5
申请日：2013-11-14
申请人： Endocyte, Inc.
发明人： VLAHOV, Iontcho Radoslavov , REDDY, Joseph Anand , BLOOMFIELD, Alicia , DORTON, Ryan , NELSON, Melissa , VETZEL, Marilynn , LEAMON, Christopher Paul
CPC分类号： A61K47/64 , A61K38/00 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/542 , A61K47/547 , A61K49/0002 , A61K51/04 , C07K5/021 , C07K5/06113 , C07K5/10 , C07K5/1019
摘要： The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.
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