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1.发明授权
公开(公告)号：EP2158319B1
公开(公告)日：2011-12-07
申请号：EP08757088.3
申请日：2008-05-12
申请人： Enobia Pharma Inc.
发明人： CRINE, Philippe , BOILEAU, Guy , LOISEL, Thomas, P. , LEMIRE, Isabelle , LEONARD, Pierre , HEFT, Robert , LANDY, Hal
CPC分类号： C12N9/16 , A61K38/00 , C07K2319/33 , C12N2799/025 , C12Y301/03001
摘要： A bone targeted alkaline phosphatase comprising a polypeptide having the structure : Z-sALP-Y-spacer-X-Wn-V, wherein sALP is the extracellular domain of the alkaline phosphatase; wherein V is absent or is an amino acid sequence of at least one amino acid; X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Wn is a polyaspartate or a polyglutamate wherein n = 10 to 16. Kits and methods of use thereof.
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2.发明公开
公开(公告)号：EP2158319A1
公开(公告)日：2010-03-03
申请号：EP08757088.3
申请日：2008-05-12
申请人： Enobia Pharma Inc.
发明人： CRINE, Philippe , BOILEAU, Guy , LOISEL, Thomas, P. , LEMIRE, Isabelle , LEONARD, Pierre , HEFT, Robert , LANDY, Hal
CPC分类号： C12N9/16 , A61K38/00 , C07K2319/33 , C12N2799/025 , C12Y301/03001
摘要： A bone targeted alkaline phosphatase comprising a polypeptide having the structure : Z-sALP-Y-spacer-X-Wn-V, wherein sALP is the extracellular domain of the alkaline phosphatase; wherein V is absent or is an amino acid sequence of at least one amino acid; X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Wn is a polyaspartate or a polyglutamate wherein n = 10 to 16. Kits and methods of use thereof.
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3.发明授权
公开(公告)号：EP1759001B1
公开(公告)日：2011-04-13
申请号：EP05739065.0
申请日：2005-04-21
申请人： Enobia Pharma Inc.
CPC分类号： C07K7/06 , A61K38/00 , A61K47/645 , C07K14/51 , C07K2319/01 , C07K2319/23 , C12N9/16 , C12N9/6421 , C12N9/6494 , C12Y301/03001 , C12Y304/24011
摘要： A bone delivery conjugate having a structure selected from the group consisting of :A) X-D n -Y-protein-Z; and B) Z-protein-Y- D n -X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and D n is a poly aspartate wherein n = 10 to 16. Compositions comprising same and uses thereof.
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4.发明公开
公开(公告)号：EP1759001A1
公开(公告)日：2007-03-07
申请号：EP05739065.0
申请日：2005-04-21
申请人： Enobia Pharma Inc.
IPC分类号： C12N15/57 , A61K38/46 , A61K38/48 , A61K47/48 , C12N15/55 , C12N9/50 , C12N9/14 , A61P19/08 , G01N33/68
CPC分类号： C07K7/06 , A61K38/00 , A61K47/645 , C07K14/51 , C07K2319/01 , C07K2319/23 , C12N9/16 , C12N9/6421 , C12N9/6494 , C12Y301/03001 , C12Y304/24011
摘要： A bone delivery conjugate having a structure selected from the group consisting of :A) X-D n -Y-protein-Z; and B) Z-protein-Y- D n -X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and D n is a poly aspartate wherein n = 10 to 16. Compositions comprising same and uses thereof.
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