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    PAN-DR BINDING POLYPEPTIDES AND USES THEREOF
    3.
    发明公开
    PAN-DR BINDING POLYPEPTIDES AND USES THEREOF 有权
    PAN-DR-BINDENDE POLYPEPTIDE UND VERWENDUNGEN DAVON

    公开(公告)号：EP2391635A2

    公开(公告)日：2011-12-07

    申请号：EP10702087.7

    申请日：2010-01-26

    申请人： Epimmune Inc.

    发明人： DEGAN, Florence Dal ,  NEWMAN, Mark J. ,  ALEXANDER, Jeffery L. ,  SOUTHWOOD, Scott

    IPC分类号： C07K7/04 ,  C07K14/435

    CPC分类号： A61K39/39 ,  A61K2039/55516 ,  C07K7/08 ,  C07K2319/00

    摘要： The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX
    1 FVAAX
    2 TLX
    3 AX
    4 A (SEQ ID NO : 1), wherein X
    1 is selected from the group consisting of W, F, Y, H, D, E, N, Q, I and K; X
    2 is selected from the group consisting of F, N, Y and W; X
    3 is selected from the group consisting of H and K, and X
    4 is selected from the group consisting of A, D and E, with the proviso that the oligopeptide sequence is not AKFV AAWTLKAAA. The invention also relates to larger peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.

    摘要翻译： 本发明提供能够结合由几个等位基因编码的HLA II类分子的新型人造寡肽。 寡肽包括序列AX1FVAAX2TLX3AX4A（SEQ ID NO：1），其中X1选自W，F，Y，H，D，E，N，Q，I和K; X2选自F，N，Y和W; X 3选自H和K，X 4选自A，D和E，条件是寡肽序列不是AKFVAAWTLKAAA。 本发明还涉及包含寡肽，编码寡肽和较大肽的多核苷酸的较大肽，以及包含寡肽，肽或多核苷酸的组合物。 还公开了诱导免疫应答的方法。