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公开(公告)号：EP4252851A2
公开(公告)日：2023-10-04
申请号：EP23174369.1
申请日：2015-06-17
发明人： KEILHACK, Heike , OTTESEN, Lone , REYDERMAN, Larisa , JOHNSTON, L. Danielle , KNUTSON, Sarah K.
IPC分类号： A61P35/00
摘要： The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.
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公开(公告)号：EP3157527A1
公开(公告)日：2017-04-26
申请号：EP15809540.6
申请日：2015-06-17
发明人： KEILHACK, Heike , OTTESEN, Lone , REYDERMAN, Larisa , JOHNSTON, L. Danielle , KNUTSON, Sarah K.
IPC分类号： A61K31/5377 , A61K31/4412 , A61K31/444 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/4412 , A61K31/4545
摘要： The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.
摘要翻译： 本发明涉及通过将EZH2抑制剂或其药物组合物施用于有此需要的受试者来治疗癌症的方法。 本权利要求书定义了治疗非何杰金氏淋巴瘤的特定亚型的方法，包括向受试者施用EZH2抑制剂。 优选的EZH2抑制剂包括tazemetostat（EPZ-6438 E7438）和其他化合物。 剂量和体制也被定义。
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公开(公告)号：EP4252851A3
公开(公告)日：2023-11-22
申请号：EP23174369.1
申请日：2015-06-17
发明人： KEILHACK, Heike , OTTESEN, Lone , REYDERMAN, Larisa , JOHNSTON, L. Danielle , KNUTSON, Sarah K.
IPC分类号： A61K31/4412 , A61K31/5377 , A61K31/444 , A61P35/00 , A61P35/02
摘要： The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and their use for the treatment of cancer.
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公开(公告)号：EP3057594A1
公开(公告)日：2016-08-24
申请号：EP14854576.7
申请日：2014-10-17
发明人： KEILHACK, Heike , KNUTSON, Sarah K.
IPC分类号： A61K31/5377 , A61K31/4412 , A61K31/444 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/4412 , A61K31/444 , A61K31/4545
摘要： The present invention relates to methods of treating cancer by administering an EZH2 inhibitor or a pharmaceutical composition thereof to subject in need thereof.
摘要翻译： 本发明涉及通过给有此需要的受试者施用EZH2抑制剂或其药物组合物来治疗癌症的方法。
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公开(公告)号：EP3370725A1
公开(公告)日：2018-09-12
申请号：EP16863176.0
申请日：2016-11-07
申请人： Epizyme, Inc.
IPC分类号： A61K31/5355 , A61K31/497 , A61K31/4433 , A61K31/4436 , A61P35/00
CPC分类号： A61K31/4433 , A61K31/4412 , A61K31/4436 , A61K31/4468 , A61K31/496 , A61K31/501 , A61K31/5377
摘要： The disclosure provides a method of treating a an INI1-deficient tumor in a subject in need thereof comprising administering to the subject a therapeutically-effective amount of an enhancer of a zeste homolog 2 (EZH2) inhibitor. In a preferred embodiment of this method, the subject is pediatric and the EZH2 inhibitor is Tazemetostat.
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公开(公告)号：EP3076977A1
公开(公告)日：2016-10-12
申请号：EP14868382.4
申请日：2014-12-08
申请人： Epizyme, Inc.
IPC分类号： A61K31/5377 , A61K31/4412 , A61P35/00 , A61P35/02
CPC分类号： A61K31/5377 , A61K31/404 , A61K31/436 , A61K31/4375 , A61K31/496 , A61K31/4965 , A61K31/519 , A61K31/52 , A61K31/573 , A61K31/635 , A61K31/675 , A61K31/69 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2887 , A61K2300/00
摘要： The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
摘要翻译： 本发明涉及包含人组蛋白甲基转移酶EZH2抑制剂和一种或多种其他治疗剂（特别是抗癌剂，如泼尼松）的组合物，以及用于向有需要的受试者施用以治疗癌症的组合疗法的方法。
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公开(公告)号：EP3888659A1
公开(公告)日：2021-10-06
申请号：EP21159972.5
申请日：2014-12-08
申请人： Epizyme Inc
IPC分类号： A61K31/5377 , A61K31/4412 , A61P35/00 , A61P35/02 , A61K45/06 , A61K31/537 , A61K31/436 , A61K31/404 , A61K31/4375 , A61K31/496 , A61K31/4965 , A61K31/519 , A61K31/52 , A61K31/573 , A61K31/635 , A61K31/675 , A61K31/69 , A61K39/00 , A61K39/395
摘要： The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：EP3341080A1
公开(公告)日：2018-07-04
申请号：EP16840037.2
申请日：2016-08-24
申请人： Epizyme Inc
发明人： KEILHACK, Heike , KNUTSON, Sarah K.
IPC分类号： A61P35/02 , A61K31/4412 , A61K31/4433 , A61K31/5377 , A61P35/00 , C07D405/12
CPC分类号： A61K31/5377 , A61K9/0053 , A61K31/4412 , A61K31/4545 , A61P35/00
摘要： The present disclosure relates to pharmaceutical compositions comprising inhibitor(s) of human histone methyltransferase EZH2, and methods of cancer therapy using the EZH2 inhibitor(s).
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公开(公告)号：EP3307713A1
公开(公告)日：2018-04-18
申请号：EP16808443.2
申请日：2016-06-10
申请人： Epizyme, Inc.
IPC分类号： C07D213/50 , C07D401/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , A61K31/4412 , A61K31/444 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/4412 , A61K31/444 , A61K31/475 , A61K31/573 , A61K31/675 , A61K31/704 , A61K39/39558 , A61K45/06 , A61P35/00 , G01N33/57407 , A61K2300/00
摘要： The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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