公开(公告)号：EP4223878A1

公开(公告)日：2023-08-09

申请号：EP21875877.9

申请日：2021-10-01

申请人： Epsilon Molecular Engineering Inc. ,  The Kitasato Institute ,  Kao Corporation

发明人： MASAKI, Hidekazu ,  KUMACHI, Shigefumi ,  YONEHARA, Ryo ,  MATSUMURA, Yuta ,  KAWANO, Hibiki ,  TOJO, Takuto ,  MORIMOTO, Takuya ,  KATAYAMA, Kazuhiko ,  HAGA, Kei ,  TODAKA, Reiko ,  SAWADA, Akihito ,  TAKANO, Tomomi

IPC分类号： C12N15/13 ,  A61K39/215 ,  A61P31/14 ,  C07K16/10 ,  C07K16/46

摘要： A peptide which binds to SARS-CoV-2 and its usage are provided. The peptide which binds to SARS-CoV-2 comprises one or more structural domain comprising CDR3 consisting of an amino acid sequence of any of SEQ ID NOs: 1 to 9 or an amino acid sequence obtained by substituting at least one amino acid in the amino acid sequence with another amino acid.

公开(公告)号：EP4299745A1

公开(公告)日：2024-01-03

申请号：EP22759586.5

申请日：2022-02-21

申请人： Kao Corporation ,  Epsilon Molecular Engineering Inc.

发明人： INAURA, Shunsuke ,  MATSUMURA, Yuta ,  TOJO, Takuto ,  NAGAMI, Atsushi

IPC分类号： C12N15/13 ,  A61K39/395 ,  A61P31/14 ,  A61P43/00 ,  C07K16/10 ,  C07K19/00 ,  G01N33/569

摘要： Provided is an antibody that binds to the N-protein of SARS-CoV-2, and a method for utilizing the antibody. An antibody that binds to SARS-CoV-2, having one or more structural domains comprising CDRs shown in the following (a) or (b): (a) CDR1 consisting of the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence obtained by substituting one amino acid with another amino acid in the amino acid sequence, CDR2 consisting of the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence obtained by substituting one amino acid with another amino acid in the amino acid sequence, and CDR3 consisting of the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence obtained by substituting one amino acid with another amino acid in the amino acid sequence; or (b) CDR1 consisting of the amino acid sequence of SEQ ID NO: 4 or an amino acid sequence obtained by substituting one amino acid with another amino acid in the amino acid sequence, CDR2 consisting of the amino acid sequence of SEQ ID NO: 5 or an amino acid sequence obtained by substituting one amino acid with another amino acid in the amino acid sequence, and CDR3 consisting of the amino acid sequence of SEQ ID NO: 6 or an amino acid sequence obtained by substituting one amino acid with another amino acid in the amino acid sequence.