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公开(公告)号：EP3233840B1
公开(公告)日：2018-11-21
申请号：EP15830780.1
申请日：2015-12-14
IPC分类号： C07D405/12 , A61K31/416 , C07D231/56 , A61P35/00 , A61P25/28 , A61P25/16 , A61P29/00
CPC分类号： C07D231/56 , A61P25/28 , A61P29/00 , A61P35/00 , C07D261/20 , C07D405/12
摘要： The present invention relates to novel heterocyclic derivatives having general formula (I) and their therapeutic use for diseases such as cancer, inflammation, pain, autoimmune diseases or neurodegenerative diseases like Alzheimer's or Parkinson's disease that can be treated by modulation of certain protein kinases. Compounds of formula (I) can be used for treatment of patients who do not respond to kinase inhibition therapy that comprises currently available medications.
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公开(公告)号：EP3233840A1
公开(公告)日：2017-10-25
申请号：EP15830780.1
申请日：2015-12-14
IPC分类号： C07D405/12 , A61K31/416 , C07D231/56 , A61P35/00 , A61P25/28 , A61P25/16 , A61P29/00
CPC分类号： C07D231/56 , A61P25/28 , A61P29/00 , A61P35/00 , C07D261/20 , C07D405/12
摘要： The present invention relates to novel heterocyclic derivatives having general formula (I) and their therapeutic use for diseases such as cancer, inflammation, pain, autoimmune diseases or neurodegenerative diseases like Alzheimer's or Parkinson's disease that can be treated by modulation of certain protein kinases. Compounds of formula (I) can be used for treatment of patients who do not respond to kinase inhibition therapy that comprises currently available medications.
摘要翻译： 本发明涉及具有通式（I）的新型杂环衍生物及其对诸如癌症，炎症，疼痛，自身免疫疾病或可通过调节某些蛋白激酶来治疗的阿尔茨海默病或帕金森病等神经退行性疾病的疾病的治疗用途。 式（I）化合物可用于治疗对包含现有药物的激酶抑制疗法无应答的患者。
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公开(公告)号：EP3620452A1
公开(公告)日：2020-03-11
申请号：EP18193196.5
申请日：2018-09-07
IPC分类号： C07D215/233
摘要： The present invention relates to a process for the preparation of Lenvatinib of formula (I) from 4-amino-3-chloro-phenol and 4-chloro-7-methoxyquinoline-6-carboxamide.
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