公开(公告)号：EP3320019A1

公开(公告)日：2018-05-16

申请号：EP16745630.0

申请日：2016-06-21

申请人： Evonik Röhm GmbH

发明人： KIRCHNER, Andreas ,  LIZIO, Rosario ,  ROSSMEISSL, Markus Rolf ,  LULEY, Wolfgang ,  VORHOLZ, Johannes ,  GRIMM, Silko ,  SCHNEIDER, Marc

IPC分类号： C08G63/88 ,  C08J9/14 ,  C08J9/20

摘要： A process for preparing poly(lactide-co-glycolide) copolymer particles with an average particle size in the range of 50-800 nm includes transferring a mixture of poly(lactide-co-glycolide) copolymer, ethanol and carbon dioxide from a first reactor into a second reactor under rapid reduction of the pressure and expansion with phase separation into a gas phase, an ethanol aerosol and an ethanolic suspension containing poly(lactide-co-glycolide) copolymer particles, removing the carbon dioxide gas and the ethanol aerosol from the second reactor, and obtaining the poly(glycolide-co-lactide) copolymer particles in the form of an ethanolic suspension or in dry form from the second reactor.