公开(公告)号：EP1979329A2

公开(公告)日：2008-10-15

申请号：EP07717132.0

申请日：2007-01-30

申请人： Exelixis, Inc.

发明人： MANN, Grace ,  AAY, Naing ,  ARCALAS, Arlyn ,  BROWN, S. David ,  CHAN, Wai Ki Vicky ,  CHEN, Jeff ,  DU, Hongwang ,  EPSHTEYN, Sergey ,  FORSYTH, Timothy, Patrick ,  GALAN, Adam A. ,  HUYNH, Tai Phat ,  IBRAHIM, Mohamed Abdulkader ,  JOHNSON, Henry William Beecroft ,  KANE, Brian ,  KEARNEY, Patrick ,  KIM, Byung Gyu ,  KOLTUN, Elena ,  LEAHY, James W. ,  LEE, Matthew Sangyup ,  LEWIS, Gary L. ,  MEYR, Lisa E. ,  NOGUCHI, Robin Tammie ,  PACK, Michael ,  RIDGWAY, Brian Hugh ,  SHI, Xian ,  WOOLFREY, John ,  ZHOU, Peiwen

IPC分类号： C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D453/02 ,  C07D487/04

摘要： This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.