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公开(公告)号：EP1948617B1
公开(公告)日：2011-07-27
申请号：EP06826578.4
申请日：2006-10-23
申请人： Exelixis, Inc.
发明人： RICE, Kenneth D. , ANAND, Neel Kumar , ARCALAS, Arlyn , BLAZEY, Charles M. , BUSSENIUS, Joerg , CHAN, Wai Ki Vicky , DU, Hongwang , EPSHTEYN, Sergey , IBRAHIM, Mohamed Abdulkader , KEARNEY, Patrick , KENNEDY, Abigail R. , KIM, Moon Hwan , MANALO, Jean-Claire Limun , PETO, Csaba J. , TSANG, Tsze H. , TSUHAKO, Amy Lew , ZHOU, Peiwen , KOLTUN, Elena, S.
IPC分类号： C07D237/36 , C07D239/46 , C07D401/04 , C07D403/04 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D487/04
摘要： A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1 and R2 are defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
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公开(公告)号：EP1648455A2
公开(公告)日：2006-04-26
申请号：EP04779018.3
申请日：2004-07-23
申请人： Exelixis, Inc.
发明人： ANAND, Neel Kumar , BLAZEY, Charles M. , BOWLES, Owen Joseph , BUSSENIUS, Joerg , COSTANZO, Simona , CURTIS, Jeffry Kimo , DUBENKO, Larisa , KENNEDY, Abigail R. , KHOURY, Richard G. , KIM, Angie I. , MANALO, Jean-Claire L. , PETO, Csaba J. , RICE, Kenneth D. , TSANG, Tsze H.
IPC分类号： A61K31/437 , C07D471/04 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04 , C07D491/147 , C07D519/00
摘要： The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.
摘要翻译： 本发明包括含有作为ALK抑制剂的化合物的化合物和药物组合物。 本发明还包括使用所述化合物和组合物治疗由ALK介导的疾病的方法，所述疾病包括诸如癌症，免疫疾病，心血管疾病和其他退行性疾病的疾病。
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3.发明授权
公开(公告)号：EP1934174B1
公开(公告)日：2011-04-06
申请号：EP06825554.6
申请日：2006-10-05
申请人： Exelixis, Inc.
发明人： AAY, Naing , ANAND, Neel Kumar , BOWLES, Owen Joseph , BUSSENIUS, Joerg , COSTANZO, Simona , CURTIS, Jeffry Kimo , DUBENKO, Larisa , JOSHI, Anagha Abhijit , KENNEDY, Abigail R. , KIM, Angie Inyoung , KOLTUN, Elena , MANALO, Jean-Claire Limun , PETO, Csaba J. , RICE, Kenneth D. , TSANG, Tsze H. , DeFINA, Steven Charles , BLAZEY, Charles M.
IPC分类号： C07D205/04 , C07D205/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
CPC分类号： C07D205/04 , C07D205/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
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公开(公告)号：EP1948663A2
公开(公告)日：2008-07-30
申请号：EP06826579.2
申请日：2006-10-23
申请人： Exelixis, Inc.
发明人： RICE, Kenneth D. , BUSSENIUS, Joerg , COSTANZO, Simona , KENNEDY, Abigail R. , KIM, Angie Inyoung , MANALO, Jean-Claire Limun , PETO, Csaba J.
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： A compound according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R6, R7 and Z are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
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公开(公告)号：EP1948663B1
公开(公告)日：2011-09-14
申请号：EP06826579.2
申请日：2006-10-23
申请人： Exelixis, Inc.
发明人： RICE, Kenneth D. , BUSSENIUS, Joerg , COSTANZO, Simona , KENNEDY, Abigail R. , KIM, Angie Inyoung , MANALO, Jean-Claire Limun , PETO, Csaba J.
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： A compound according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R6, R7 and Z are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
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公开(公告)号：EP2074120B1
公开(公告)日：2010-03-03
申请号：EP08832769.7
申请日：2008-10-27
申请人： Exelixis, Inc.
发明人： RICE, Kenneth D. , AAY, Naing , ARCALAS, Arlyn , BAIK, Tae-Gon , BLAZEY, Charles M. , BOWLES, Owen Joseph , BUHR, Chris A. , BUSSENIUS, Joerg , COSTANZO, Simona , CURTIS, Jeffry Kimo , DEFINA, Steven Charles , DUBENKO, Larisa , KENNEDY, Abigail R. , KIM, Angie Inyoung , LARA, Katherine , MA, Sunghoon , MANALO, Jean-Claire Limun , PETO, Csaba J. , TSANG, Tsze H. , WANG, Longcheng , ANAND, Neel Kumar
IPC分类号： C07D451/02 , A61K31/46 , A61P35/00
CPC分类号： C07D451/02
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公开(公告)号：EP2074120A1
公开(公告)日：2009-07-01
申请号：EP08832769.7
申请日：2008-10-27
申请人： Exelixis, Inc.
发明人： RICE, Kenneth D. , AAY, Naing , ARCALAS, Arlyn , BAIK, Tae-Gon , BLAZEY, Charles M. , BOWLES, Owen Joseph , BUHR, Chris A. , BUSSENIUS, Joerg , COSTANZO, Simona , CURTIS, Jeffry Kimo , DEFINA, Steven Charles , DUBENKO, Larisa , KENNEDY, Abigail R. , KIM, Angie Inyoung , LARA, Katherine , MA, Sunghoon , MANALO, Jean-Claire Limun , PETO, Csaba J. , TSANG, Tsze H. , WANG, Longcheng , ANAND, Neel Kumar
IPC分类号： C07D451/02 , A61K31/46 , A61P35/00
CPC分类号： C07D451/02
摘要： A compound according to Formula I or II: (I) or (II) wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 根据式I或II的化合物：其中R1，R1b，R2，L1和L2和L2b如说明书中所定义的式（I）或（II）化合物，其药物组合物及其使用方法。
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公开(公告)号：EP1948617A2
公开(公告)日：2008-07-30
申请号：EP06826578.4
申请日：2006-10-23
申请人： Exelixis, Inc.
发明人： RICE, Kenneth D. , ANAND, Neel Kumar , ARCALAS, Arlyn , BLAZEY, Charles M. , BUSSENIUS, Joerg , CHAN, Wai Ki Vicky , DU, Hongwang , EPSHTEYN, Sergey , IBRAHIM, Mohamed Abdulkader , KEARNEY, Patrick , KENNEDY, Abigail R. , KIM, Moon Hwan , MANALO, Jean-Claire Limun , PETO, Csaba J. , TSANG, Tsze H. , TSUHAKO, Amy Lew , ZHOU, Peiwen , KOLTUN, Elena, S.
IPC分类号： C07D237/36 , C07D239/46 , C07D401/04 , C07D403/04 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D487/04
摘要： A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1 and R2 are defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
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9.发明公开
公开(公告)号：EP1934174A1
公开(公告)日：2008-06-25
申请号：EP06825554.6
申请日：2006-10-05
申请人： Exelixis, Inc.
发明人： AAY, Naing , ANAND, Neel Kumar , BOWLES, Owen Joseph , BUSSENIUS, Joerg , COSTANZO, Simona , CURTIS, Jeffry Kimo , DUBENKO, Larisa , JOSHI, Anagha Abhijit , KENNEDY, Abigail R. , KIM, Angie Inyoung , KOLTUN, Elena , MANALO, Jean-Claire Limun , PETO, Csaba J. , RICE, Kenneth D. , TSANG, Tsze H. , DeFINA, Steven Charles , BLAZEY, Charles M.
IPC分类号： C07D205/04 , C07D205/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
CPC分类号： C07D205/04 , C07D205/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
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