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1.发明公开BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE 审中-公开AS PI3K / mTOR抑制剂Benzoxazepines使用和制造方法
公开(公告)号：EP2640367A2
公开(公告)日：2013-09-25
申请号：EP11788001.3
申请日：2011-11-15
申请人： Exelixis, Inc.
发明人： RICE, Kenneth , MARKBY, David
CPC分类号： A61K31/553 , A61K31/00 , A61K31/437 , A61K31/519 , A61K45/06 , C12Q1/6886 , G01N33/574 , A61K2300/00
摘要： The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of treating using the compounds, methods for screening for inhibitor compounds and methods for identifying treatment regimens.
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2.发明公开BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE 审中-公开苯并恶嗪作为PI3K / MTOR的抑制剂及其使用和制造方法
公开(公告)号：EP2643319A1
公开(公告)日：2013-10-02
申请号：EP11793623.7
申请日：2011-11-23
申请人： Exelixis, Inc.
发明人： RICE, Kenneth
IPC分类号： C07D413/14 , A61K31/423
CPC分类号： C07D413/14
摘要： The invention is directed to inhibitors of PI3K and mTOR and pharmaceutically acceptable salts or solvates thereof, as well as methods of using them, wherein the inhibitors are of structural Formula I and pharmaceutically acceptable salts thereof, wherein the variables are as defined herein.
摘要翻译： 本发明涉及PI3K和mTOR的抑制剂及其药学上可接受的盐或溶剂化物，以及使用它们的方法，其中所述抑制剂具有结构式I及其药学上可接受的盐，其中变量如本文所定义。
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3.发明公开BENZOXAZEPINES AS INHIBITORS OF P13K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE 审中-公开AS P13K / mTOR抑制剂Benzoxazepines使用和制造方法
公开(公告)号：EP2643316A2
公开(公告)日：2013-10-02
申请号：EP11794897.6
申请日：2011-11-23
申请人： Exelixis, Inc.
发明人： RICE, Kenneth
IPC分类号： C07D413/04
CPC分类号： C07D413/14 , C07D413/04 , C07D413/06 , C07D417/14 , C07D451/02 , C07D451/06 , C07D451/12 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D513/04 , C07D519/00
摘要： The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
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4.发明公开BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE 审中-公开Benzoxazepines mTOR抑制剂使用和制造方法
公开(公告)号：EP2643327A1
公开(公告)日：2013-10-02
申请号：EP11790718.8
申请日：2011-11-23
申请人： Exelixis, Inc.
发明人： RICE, Kenneth
IPC分类号： C07D513/04 , A61K31/437
CPC分类号： C07D513/04 , C07D471/04
摘要： The invention is directed to inhibitors of mTOR and pharmaceutically acceptable salts or solvates thereof, as well as methods of using them. The inhibitors are generally of structural Formula (I) wherein the variables are as defined herein.
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5.发明公开BENZOXAZEPINES AS INHIBITORS OF P13K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE 审中-公开苯并恶嗪作为P13K / MTOR的抑制剂及其使用和制造方法
公开(公告)号：EP2643317A1
公开(公告)日：2013-10-02
申请号：EP11805679.5
申请日：2011-11-23
申请人： Exelixis, Inc.
发明人： RICE, Kenneth , FOSTER, Paul
IPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/14 , A61K31/553 , A61K35/00
CPC分类号： C07D513/04 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/14
摘要： The invention is directed 10 Compound's of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂化物，以及制备和使用该化合物的方法。
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6.发明公开BENZOXAZEPINES AS INHIBITORS OF P13K/mTOR AND METHODS OF THEIR USE AND MANUFACTURE 审中-公开苯并恶嗪作为P13K / mTOR的抑制剂及其使用和制造方法
公开(公告)号：EP2643315A1
公开(公告)日：2013-10-02
申请号：EP11791722.9
申请日：2011-11-23
申请人： Exelixis, Inc.
发明人： RICE, Kenneth
IPC分类号： C07D413/04 , C07D413/14 , C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： C07D413/14 , C07D413/04 , C07D471/04
摘要： The invention is directed to inhibitors of mTOR and pharmaceutically acceptable salts or solvates thereof, as well as methods of using them. The inhibitors are generally of structural formula I and pharmaceutically acceptable salts thereof, wherein the variables are as defined herein.
摘要翻译： 本发明涉及mTOR的抑制剂及其药学上可接受的盐或溶剂化物，以及使用它们的方法。 抑制剂通常具有结构式I及其药学上可接受的盐，其中变量如本文所定义。
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7.发明公开BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE 审中-公开AS PI3K / mTOR抑制剂Benzoxazepines和方法供其使用
公开(公告)号：EP2640366A2
公开(公告)日：2013-09-25
申请号：EP11787999.9
申请日：2011-11-15
申请人： Exelixis, Inc.
发明人： RICE, Kenneth , MARKBY, David
CPC分类号： C07D471/04 , A61K31/437 , A61K31/519 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D413/14 , C12Q1/485 , C12Q1/6886 , G01N33/5748 , A61K2300/00
摘要： The invention is directed to Compounds of Formula I: (I) and pharmaceutically acceptable salts or solvates thereof, as well as methods of treating using the compounds, methods for screening for inhibitor compounds and methods for identifying treatment regimens.
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