公开(公告)号：EP1448189A2

公开(公告)日：2004-08-25

申请号：EP02790352.5

申请日：2002-11-11

申请人： F. HOFFMANN-LA ROCHE AG

发明人： BREIMER, Lars, Holger ,  DHINGRA, Kapil ,  DHINGRA, Urvashi Hooda ,  RITLAND, Steve

IPC分类号： A61K31/404 ,  A61K31/7068 ,  A61P35/00

CPC分类号： A61K31/404 ,  A61K31/7068 ,  A61K31/7072 ,  A61K2300/00

摘要： The present invention relates to the use of a pharmaceutical combination comprising as a active ingredients a) a component consisting of pharmaceutical composition comprising a compound of formula (I) as defined in the description and claims and b) a component consisting of pharmaceutical composition comprising as an active ingredient gemcitabine for the preparation of a medicament for the treatment of patients suffering with cancer.

公开(公告)号：EP1359979B1

公开(公告)日：2006-04-26

申请号：EP02714140.7

申请日：2002-02-01

申请人： F. HOFFMANN-LA ROCHE AG

发明人： BREIMER, Lars, Holger ,  DHINGRA, Kapil ,  DHINGRA, Urvashi, Hooda ,  RITLAND, Steve

IPC分类号： A61P35/00 ,  A61K31/404 ,  A61K31/337

CPC分类号： A61K31/337 ,  A61K31/404 ,  A61K31/40 ,  A61K31/335 ,  A61K2300/00

摘要： Disclosed is a process of treating a patient suffering from cancer. The process compriese administering to a patient over a period of up to about 15 days a first component and a second component. The first component consists of a pharmaceutical composition containin as an active ingreadient a compound of formula (I) or a pharmaceutically acceptable salt or ester of said compound. the second ocmponenet consists of a n injection solution containing as an active ingredient paclitaxel. The amount of each componet in the combination is such that the combination is therapeutically effective. The components are administered concomitantly or sequentially ina three week to four week treatment cycle for as long as the tumor remains under control and the patient tolerates the regimen.

公开(公告)号：EP1359979A2

公开(公告)日：2003-11-12

申请号：EP02714140.7

申请日：2002-02-01

申请人： F. HOFFMANN-LA ROCHE AG

发明人： BREIMER, Lars, Holger ,  DHINGRA, Kapil ,  DHINGRA, Urvashi, Hooda ,  RITLAND, Steve

IPC分类号： A61P35/00 ,  A61K31/404

CPC分类号： A61K31/337 ,  A61K31/404 ,  A61K31/40 ,  A61K31/335 ,  A61K2300/00

摘要： Disclosed is a process of treating a patient suffering from cancer. The process compriese administering to a patient over a period of up to about 15 days a first component and a second component. The first component consists of a pharmaceutical composition containin as an active ingreadient a compound of formula (I) or a pharmaceutically acceptable salt or ester of said compound. the second ocmponenet consists of a n injection solution containing as an active ingredient paclitaxel. The amount of each componet in the combination is such that the combination is therapeutically effective. The components are administered concomitantly or sequentially ina three week to four week treatment cycle for as long as the tumor remains under control and the patient tolerates the regimen.