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1.发明授权4-ALKENYL (AND ALKYNYL) OXINDOLES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES, IN PARTICULAR CDK2 有权4 - 烯基（和炔基）氧代吲哚作为抑制剂细胞周期蛋白依赖性激酶，特别是CDK2
公开(公告)号：EP1157019B1
公开(公告)日：2003-03-19
申请号：EP99963422.3
申请日：1999-12-08
发明人： CHEN, Yi , CORBETT, Wendy, Lea , DERMATAKIS, Apostolos , LIU, Jin-Jun , LUK, Kin-Chun , MAHANEY, Paige E. , MISCHKE, Steven Gregory
IPC分类号： C07D403/06 , A61K31/40 , C07D405/14 , C07D409/14 , C07D401/14 , C07D403/14
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14
摘要： Novel 4-alkenyl- and 4-alkynyl oxindoles having formulas (I) and (II) and the pharmaceutically acceptable salts thereof, wherein R?1, R2, R3¿, a, b, and X are as defined herein inhibit cyclin-dependent kinases (CDKs), in particular CDK2 and are useful as anti-proliferative agents in the treatment or control of cell proliferative disorders, in particular breast and colon tumors.
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2.发明公开4-ALKENYL (AND ALKYNYL) OXINDOLES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES, IN PARTICULAR CDK2 有权4 - 烯基（和炔基）的羟吲哚作为抑制剂细胞周期蛋白依赖性激酶，特别是CDK2
公开(公告)号：EP1157019A1
公开(公告)日：2001-11-28
申请号：EP99963422.3
申请日：1999-12-08
发明人： CHEN, Yi , CORBETT, Wendy, Lea , DERMATAKIS, Apostolos , LIU, Jin-Jun , LUK, Kin-Chun , MAHANEY, Paige E. , MISCHKE, Steven Gregory
IPC分类号： C07D403/06 , A61K31/40 , C07D405/14 , C07D409/14 , C07D401/14 , C07D403/14
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14
摘要： Novel 4-alkenyl- and 4-alkynyl oxindoles having formulas (I) and (II) and the pharmaceutically acceptable salts thereof, wherein R?1, R2, R3¿, a, b, and X are as defined herein inhibit cyclin-dependent kinases (CDKs), in particular CDK2 and are useful as anti-proliferative agents in the treatment or control of cell proliferative disorders, in particular breast and colon tumors.
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