公开(公告)号：EP0813065A2

公开(公告)日：1997-12-17

申请号：EP97109078.2

申请日：1997-06-05

申请人： F. HOFFMANN-LA ROCHE AG

发明人： Civelli, Olivier ,  Martin, James Richard ,  Monsma, Frederick ,  Moreau, Jean-Luc ,  Nothacker, Hans-Peter ,  Reinscheid, Rainer

IPC分类号： G01N33/566 ,  A61K38/10

CPC分类号： G01N33/9486 ,  G01N2500/00

摘要： The present invention relates to a method of screening for a therapeutically useful compound which comprises testing an LC132 receptor agonist in a screening assay for psychiatric and/or neurological disorders. More particularly, the screening method is based on contacting an LC132 receptor with an agent suspected of being an agonist of the LC132 receptor function, followed by the detection of the binding and/or the agonist activity of the compound and then testing of an agent with LC132 agonist activity in an antiepileptic, anticonvulsant or anxiolytic screening assay.

摘要翻译： 本发明涉及筛选治疗有用的化合物的方法，其包括在精神和/或神经障碍的筛选测定中检测LC132受体激动剂。 更具体地说，筛选方法是基于将LC132受体与疑似是LC132受体功能的激动剂的试剂接触，随后检测化合物的结合和/或激动剂活性，然后用 抗癫痫药，抗惊厥药或抗焦虑药筛选试验中LC132激动剂活性。