专利检索 ap:("F. HOFFMANN-LA ROCHE AG") AND inv:"McDermott, Lee Apostle" 第 1 页

1.

发明授权
PYRIMIDO 4,5-D PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY 有权
标题翻译：嘧啶并4,5-D PYRIMIDINDERIVATE MITANTIKREBSWIRKUNG

公开(公告)号：EP1560832B1

公开(公告)日：2008-01-23

申请号：EP03810410.5

申请日：2003-10-27

申请人： F. HOFFMANN-LA ROCHE AG

发明人： McDermott, Lee Apostle , KABAT, Marek, Michal , LUK, Kin-Chun , ROSSMAN, Pamela, Loreen , SO, Sung-Sau

IPC分类号： C07D487/04 , A61K31/519 , A61P35/00

CPC分类号： C07D487/04 , G01N2800/52

摘要： Disclosed are novel pyrimido compounds of the formula (I) wherein R1 to R9 are as defined in the specification, that are selective inhibitors of both KDR an FGFR kinases and are selective against LCK. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and the use for 10 treating cancer.