公开(公告)号：EP0276732B1

公开(公告)日：1993-12-01

申请号：EP88100732.2

申请日：1988-01-20

申请人： F. HOFFMANN-LA ROCHE AG

发明人： McNally, Alan Joseph ,  Schwartz, Alan ,  Usategui, Magdalena

IPC分类号： C07D311/80 ,  G01N33/535 ,  G01N33/94

CPC分类号： C07D311/80 ,  G01N33/948 ,  Y10S436/804 ,  Y10S436/805 ,  Y10S436/815

公开(公告)号：EP0276732A3

公开(公告)日：1989-02-22

申请号：EP88100732.2

申请日：1988-01-20

申请人： F. HOFFMANN-LA ROCHE AG

发明人： McNally, Alan Joseph ,  Schwartz, Alan ,  Usategui, Magdalena

IPC分类号： C07D311/80 ,  G01N33/535 ,  G01N33/94

CPC分类号： C07D311/80 ,  G01N33/948 ,  Y10S436/804 ,  Y10S436/805 ,  Y10S436/815

摘要： Novel cannabinol derivatives are provided which can be used in improved immunoassays for the detection in blood or urine samples of cannabinol metabolites. The novel cannabinol derivatives are of the formula:
where R is an
attachment chain selected from the group consisting of a p-aminophenol group or a branched or linear aminoalkyl group having from 1 to 7 carbon atoms or an organic or mineral acid addition salt thereof, an isocyanate or isothiocyanate derivative of the p-aminophenol or aminoalkyl group, a carboxyl terminated derivative of the aminoalkyl group having from 1 to 7 carbon atoms or a salt thereof, and an activated derivative of the carboxyl terminated derivative.

公开(公告)号：EP0276732A2

公开(公告)日：1988-08-03

申请号：EP88100732.2

申请日：1988-01-20

申请人： F. HOFFMANN-LA ROCHE AG

发明人： McNally, Alan Joseph ,  Schwartz, Alan ,  Usategui, Magdalena

IPC分类号： C07D311/80 ,  G01N33/535 ,  G01N33/94

CPC分类号： C07D311/80 ,  G01N33/948 ,  Y10S436/804 ,  Y10S436/805 ,  Y10S436/815

摘要： Novel cannabinol derivatives are provided which can be used in improved immunoassays for the detection in blood or urine samples of cannabinol metabolites. The novel cannabinol derivatives are of the formula:
where R is an
attachment chain selected from the group consisting of a p-aminophenol group or a branched or linear aminoalkyl group having from 1 to 7 carbon atoms or an organic or mineral acid addition salt thereof, an isocyanate or isothiocyanate derivative of the p-aminophenol or aminoalkyl group, a carboxyl terminated derivative of the aminoalkyl group having from 1 to 7 carbon atoms or a salt thereof, and an activated derivative of the carboxyl terminated derivative.

摘要翻译： 提供新的大麻酚衍生物，其可用于改进的免疫测定中用于在大麻酚代谢物的血液或尿液样品中的检测。 新型大麻酚衍生物具有下式：其中R是选自对氨基苯酚基团或具有1至7个碳原子的支链或直链氨基烷基的连接链，或有机或无机酸添加物 其盐，对氨基苯酚或氨基烷基的异氰酸酯或异硫氰酸酯衍生物，具有1至7个碳原子的氨基烷基的羧基封端的衍生物或其盐，以及羧基封端的衍生物的活化衍生物。