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1.发明授权TRICYCLIC ALKYLHYDROXAMATES, THEIR PREPARATION AND THEIR USE AS CELL PROLIFERATION INHIBITORS 有权TRIZYCLISCHE ALKYLHYDROXAMATE，生产及其作为细胞增殖抑制剂
公开(公告)号：EP1385837B1
公开(公告)日：2005-10-12
申请号：EP02724292.4
申请日：2002-04-19
IPC分类号： C07D313/12 , A61K31/335 , C07C259/06 , C07D209/88 , A61P35/00
CPC分类号： C07C259/06 , C07D209/88 , C07D313/12
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2.发明公开TRICYCLIC ALKYLHYDROXAMATES, THEIR PREPARATION AND THEIR USE AS CELL PROLIFERATION INHIBITORS 有权TRIZYCLISCHE ALKYLHYDROXAMATE，生产及其作为细胞增殖抑制剂
公开(公告)号：EP1385837A1
公开(公告)日：2004-02-04
申请号：EP02724292.4
申请日：2002-04-19
IPC分类号： C07D313/12 , A61K31/335 , C07C259/06 , C07D209/88 , A61P35/00
CPC分类号： C07C259/06 , C07D209/88 , C07D313/12
摘要： Compounds of formula (I), wherein R1, R2, A, X, Y and Z have the meanings defined in the specification, process of manufacturing these compounds and pharmaceuticals with HDAC inhibitor activity containing such a compound.
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3.发明公开ARYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开芳基吡啶磺酰胺衍生物，它们的制造和用作药物制剂
公开(公告)号：EP2148861A1
公开(公告)日：2010-02-03
申请号：EP08758506.3
申请日：2008-05-14
发明人： BROOKFIELD, Frederick , KLING, Lothar , REIFF, Ulrike , VON DER SAAL, Wolfgang , VON HIRSCHHEYDT, Thomas
IPC分类号： C07D213/71 , A61K31/435 , A61P35/00
CPC分类号： C07D213/71
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防诸如癌症之类的疾病。
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4.发明授权TETRAHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS CELL PROLIFERATION INHIBITORS 有权四氢吡啶，制备方法及其用途作为细胞增殖抑制剂
公开(公告)号：EP1353921B1
公开(公告)日：2006-04-19
申请号：EP01995721.6
申请日：2001-12-21
IPC分类号： C07D471/04 , C07D217/04 , A61K31/472 , A61P35/00
CPC分类号： C07D471/04 , C07D217/04
摘要： A compound of the formula (I) wherein A, R1, R2 and X have the meanings defined in the specification, process of manufacturing such as compound and a pharmaceutical composition with HDAC inhibitor activity and anti-cell proliferation activity containing such a compound.
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5.发明授权PYRIDONEAMIDE DERIVATIVES AS FOCAL ADHESION KINASE (FAK) INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER 有权PYRIDONAMIDDERIVATE ALS粘着斑激酶（FAK）抑制剂，及其用于治疗癌症的
公开(公告)号：EP2190834B1
公开(公告)日：2011-03-02
申请号：EP08785643.1
申请日：2008-08-20
发明人： GEORGES, Guy , KALUZA, Klaus , KOERNER, Matthias , REIFF, Ulrike , SCHEIBLICH, Stefan , VON DER SAAL, Wolfgang , WEIGAND, Stefan
IPC分类号： C07D401/12 , C07D213/82 , A61K31/444 , A61P35/00
CPC分类号： C07D213/82 , C07D401/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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6.发明公开TRICYCLIC LACTAM AND SULTAM DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS 有权三环内酰胺磺内酰胺及其衍生物及其作为抑制剂组蛋白去乙酰使用
公开(公告)号：EP1358168A1
公开(公告)日：2003-11-05
申请号：EP02714107.6
申请日：2002-01-24
IPC分类号： C07D275/06 , C07D209/92 , A61K31/403 , A61K31/428 , A61P35/00
CPC分类号： C07D275/06 , C07D209/92
摘要： A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5-7 atoms-linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proliferation.
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7.发明公开TETRAHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS CELL PROLIFERATION INHIBITORS 有权四氢吡啶，制备方法及其用途作为细胞增殖抑制剂
公开(公告)号：EP1353921A1
公开(公告)日：2003-10-22
申请号：EP01995721.6
申请日：2001-12-21
IPC分类号： C07D471/04 , C07D217/04 , A61K31/472 , A61P35/00
CPC分类号： C07D471/04 , C07D217/04
摘要： A compound of the formula (I) wherein A, R1, R2 and X have the meanings defined in the specification, process of manufacturing such as compound and a pharmaceutical composition with HDAC inhibitor activity and anti-cell proliferation activity containing such a compound.
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8.发明公开PYRIDONEAMIDE DERIVATIVES AS FOCAL ADHESION KINASE (FAK) INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER 有权PYRIDONAMIDDERIVATE ALS粘着斑激酶（FAK）抑制剂，及其用于治疗癌症的
公开(公告)号：EP2190834A1
公开(公告)日：2010-06-02
申请号：EP08785643.1
申请日：2008-08-20
发明人： GEORGES, Guy , KALUZA, Klaus , KOERNER, Matthias , REIFF, Ulrike , SCHEIBLICH, Stefan , VON DER SAAL, Wolfgang , WEIGAND, Stefan
IPC分类号： C07D401/12 , C07D213/82 , A61K31/444 , A61P35/00
CPC分类号： C07D213/82 , C07D401/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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9.发明授权TRICYCLIC LACTAM AND SULTAM DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS 有权三环内酰胺磺内酰胺及其衍生物及其作为抑制剂组蛋白去乙酰使用
公开(公告)号：EP1358168B1
公开(公告)日：2005-08-10
申请号：EP02714107.6
申请日：2002-01-24
IPC分类号： C07D275/06 , C07D209/92 , A61K31/403 , A61K31/428 , A61P35/00
CPC分类号： C07D275/06 , C07D209/92
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