SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS
    1.
    发明授权
    SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS 有权
    取代吲哚如α-1激动剂

    公开(公告)号:EP1501826B1

    公开(公告)日:2006-09-27

    申请号:EP03714714.7

    申请日:2003-01-23

    CPC分类号: C07D403/06 C07D495/04

    摘要: This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha- 1A/L receptor agonists, and which are represented by the general formula I wherein X is -S(O)n- or -C(O)-, A is (CI-6)-alkyl, aryl, heteroaryl, hydroxy(C 1-6)-alkyl, or -(CH2)p-NRaRb, and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, their preparation and their use as therapeutic agents.

    SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS
    2.
    发明公开
    SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS 有权
    取代吲哚如α-1激动剂

    公开(公告)号:EP1501826A2

    公开(公告)日:2005-02-02

    申请号:EP03714714.7

    申请日:2003-01-23

    CPC分类号: C07D403/06 C07D495/04

    摘要: This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha- 1A/L receptor agonists, and which are represented by the general formula I wherein X is -S(O)n- or -C(O)-, A is (CI-6)-alkyl, aryl, heteroaryl, hydroxy(C 1-6)-alkyl, or -(CH2)p-NRaRb, and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, their preparation and their use as therapeutic agents.