公开(公告)号：EP2758388B1

公开(公告)日：2018-02-21

申请号：EP12766628.7

申请日：2012-09-20

申请人： F. Hoffmann-La Roche AG

发明人： AEBI, Johannes ,  AMREIN, Kurt ,  FANTASIA, Serena, Maria ,  HORNSPERGER, Benoit ,  KUHN, Bernd ,  LIU, Yongfu ,  MAERKI, Hans P. ,  MAYWEG, Alexander, V. ,  Mohr, Peter ,  SCALONE, Michelangelo ,  TAN, Xuefei ,  ZHOU, Mingwei

IPC分类号： C07D401/04 ,  C07D471/04 ,  A61K31/4709 ,  A61P9/12

CPC分类号： C07D401/04 ,  C07D471/04

摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 A3 and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds of the present invention are useful as inhibitors of aldosterone synthase. The compounds may be used, for example, in the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.