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    IN VITRO METHOD AND APPARATUS FOR ANALYSING THE BEHAVIOUR OF SUBSTANCES IN SIMULATED PHYSIOLOGICAL ENVIRONMENT
    2.
    发明公开
    IN VITRO METHOD AND APPARATUS FOR ANALYSING THE BEHAVIOUR OF SUBSTANCES IN SIMULATED PHYSIOLOGICAL ENVIRONMENT 审中-公开
    用于分析模拟生理环境中物质的行为的体外方法和装置

    公开(公告)号：EP3183554A1

    公开(公告)日：2017-06-28

    申请号：EP15759415.1

    申请日：2015-08-19

    申请人： F. Hoffmann-La Roche AG

    发明人： JERE, Dhananjay Jagdish ,  MAHLER, Hanns-Christian ,  PATEL, Sulabh

    IPC分类号： G01N13/00

    CPC分类号： G01N13/00 ,  G01N2013/003

    摘要： The invention refers to an in vitro method and apparatus for analysing the behaviour of substances in simulated physiological environment. The method comprises the steps of providing a first fluid, a gel matrix and a second fluid, separating the first fluid and the gel matrix by at least one first semi-permeable membrane and separating the gel matrix and the second fluid by at least one second semi-permeable membrane. The method further comprises the steps of injecting a substance into the first fluid, letting the substance migrate from the first fluid through the at least one first semi-permeable membrane, through the gel matrix, through the at least one second semi-permeable membrane and into the second fluid, and determining clearance of the substance from the first fluid.

    摘要翻译： 本发明涉及用于分析模拟生理环境中的物质的行为的体外方法和设备。 该方法包括以下步骤：提供第一流体，凝胶基质和第二流体，通过至少一个第一半透膜分离第一流体和凝胶基质，并将凝胶基质和第二流体分离至少一秒 半透膜。 该方法还包括以下步骤：将物质注入第一流体中，使物质从第一流体通过至少一个第一半透膜迁移，通过凝胶基质，通过至少一个第二半透膜，以及 进入第二流体中，并且确定来自第一流体的物质的清除。