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1.发明公开NOVEL 6-FUSED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 审中-公开NOVEL 6冷凝HETEROARYLDIHYDROPYRIMIDINE用于治疗和预防乙型肝炎病毒感染的
公开(公告)号：EP3114128A1
公开(公告)日：2017-01-11
申请号：EP15710127.0
申请日：2015-03-04
发明人： GUO, Lei , HU, Taishan , KOU, Buyu , LIN, Xianfeng , SHEN, Hong , SHI, Houguang , YAN, Shixiang , ZHANG, Weixing , ZHANG, Zhisen , ZHOU, Mingwei , ZHU, Wei
IPC分类号： C07D487/04 , A61K31/4985 , C07D498/04 , C07D513/04 , A61P31/12
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/517 , A61K31/519 , C07D487/04 , C07D498/04 , C07D513/04
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供了具有以下通式的新化合物：worin R1，R2，R3，R4，R5，R6，X，Y，W和n如描述于，组合物，包括的化合物和使用所述化合物的方法。
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2.发明公开
公开(公告)号：EP3601282A1
公开(公告)日：2020-02-05
申请号：EP18716545.1
申请日：2018-03-27
发明人： DEY, Fabian , HU, Yimin , LIU, Yongqiang , LIN, Xianfeng , SHEN, Hong , SHI, Houguang , TAN, Xuefei , VERCRUYSSE, Maarten , YAN, Shixiang , ZHOU, Chengang , ZHOU, Mingwei
IPC分类号： C07D471/04 , A61K31/4375 , A61P31/04
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公开(公告)号：EP3114128B1
公开(公告)日：2019-01-02
申请号：EP15710127.0
申请日：2015-03-04
发明人： GUO, Lei , HU, Taishan , KOU, Buyu , LIN, Xianfeng , SHEN, Hong , SHI, Houguang , YAN, Shixiang , ZHANG, Weixing , ZHANG, Zhisen , ZHOU, Mingwei , ZHU, Wei
IPC分类号： C07D487/04 , A61K31/4985 , C07D498/04 , C07D513/04 , A61P31/12
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4.发明授权6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 有权6-氨基HETEROARYLDIHYDROPYRIMIDINE用于治疗和预防乙型肝炎病毒INFECTION-
公开(公告)号：EP2892893B1
公开(公告)日：2016-12-21
申请号：EP13763201.4
申请日：2013-09-06
发明人： GUO, Lei , HU, Taishan , HU, Yimin , KOCER, Buelent , LIN, Xianfeng , LIU, Haixia , MAYWEG, Alexander V. , QIU, Zongxing , SHEN, Hong , TANG, Guozhi , WANG, Lisha , WU, Guolong , YAN, Shixiang , ZHANG, Weixing , ZHOU, Mingwei , ZHU, Wei
IPC分类号： C07D401/14 , C07D413/14 , C07D403/06 , C07D409/14 , C07D417/14 , A61K31/506 , A61K31/5355 , A61P31/20
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , A61K2300/00
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：EP3887370A1
公开(公告)日：2021-10-06
申请号：EP19809440.1
申请日：2019-11-25
发明人： DEY, Fabian , HU, Yimin , LIU, Yongqiang , SHEN, Hong , SHI, Houguang , TAN, Xuefei , YAN, Shixiang , ZHANG, Weixing , ZHANG, Zhiwei , ZHOU, Chengang , ZHOU, Mingwei , ZHU, Wei
IPC分类号： C07D471/04 , C07D487/04 , A61P31/04 , A61K31/437
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公开(公告)号：EP2892893B2
公开(公告)日：2019-10-16
申请号：EP13763201.4
申请日：2013-09-06
发明人： GUO, Lei , HU, Taishan , HU, Yimin , KOCER, Buelent , LIN, Xianfeng , LIU, Haixia , MAYWEG, Alexander V. , QIU, Zongxing , SHEN, Hong , TANG, Guozhi , WANG, Lisha , WU, Guolong , YAN, Shixiang , ZHANG, Weixing , ZHOU, Mingwei , ZHU, Wei
IPC分类号： C07D401/14 , C07D413/14 , C07D403/06 , C07D409/14 , C07D417/14 , A61K31/506 , A61K31/5355 , A61P31/20
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公开(公告)号：EP3887371A1
公开(公告)日：2021-10-06
申请号：EP19809441.9
申请日：2019-11-25
发明人： DEY, Fabian , HU, Yimin , LIU, Yongqiang , SHEN, Hong , SHI, Houguang , TAN, Xuefei , YAN, Shixiang , ZHANG, Weixing , ZHANG, Zhiwei , ZHOU, Chengang , ZHOU, Mingwei , ZHU, Wei
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61P31/04
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公开(公告)号：EP3245206A1
公开(公告)日：2017-11-22
申请号：EP16700562.8
申请日：2016-01-13
发明人： HU, Taishan , HAN, Xingchun , KOU, Buyu , SHEN, Hong , YAN, Shixiang , ZHANG, Zhisen
IPC分类号： C07D487/04 , A61K31/519 , A61P31/12
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
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