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公开(公告)号：EP3380474B1
公开(公告)日：2019-08-21
申请号：EP16798788.2
申请日：2016-11-23
发明人： CHENG, Yun-Xing , GIBBONS, Paul , KELLAR, Terry , LI, Wei , MENDONCA, Rohan , YUEN, Po-wai , ZAK, Mark Edward , ZHANG, Lei
IPC分类号： C07D487/04 , A61K31/519 , A61P11/06 , A61P29/00
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2.发明公开TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开TRIAZOLOPYRIDINVERBINDUNGEN，组合物和及其使用方法
公开(公告)号：EP3041841A1
公开(公告)日：2016-07-13
申请号：EP14842356.9
申请日：2014-08-27
发明人： LI, Wei , CARTWRIGHT, Matthew W. , EDWARDS, Christine , GOODACRE, Simon C. , PATEL, Snahel , RAY, Nicholas C. , SAJAD, Mohammed , YUEN, Po-wai , ZAK, Mark E. , CHENG, Xun-Xing
IPC分类号： C07D471/04 , A61K31/41 , A61K31/437 , A61P11/06 , A61P29/00
CPC分类号： C07D519/00 , C07D471/04
摘要： Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：EP3041841B1
公开(公告)日：2019-06-05
申请号：EP14842356.9
申请日：2014-08-27
发明人： LI, Wei , CARTWRIGHT, Matthew W. , EDWARDS, Christine , GOODACRE, Simon C. , PATEL, Snahel , RAY, Nicholas C. , SAJAD, Mohammed , YUEN, Po-wai , ZAK, Mark E. , CHENG, Yun-Xing
IPC分类号： C07D471/04 , A61K31/41 , A61K31/437 , A61P11/06 , A61P29/00
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4.发明公开1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS 有权1-（HET）芳基磺酰基 - （吡咯烷或哌啶）-2-羧酰胺衍生物及其作为TRPA1拮抗剂的用途
公开(公告)号：EP3256463A1
公开(公告)日：2017-12-20
申请号：EP16703990.8
申请日：2016-02-12
发明人： ESTRADA, Anthony , VOLGRAF, Matthew , CHEN, Huifen , KOLESNIKOV, Aleksandr , VILLEMURE, Elisia , VERMA, Vishal , WANG, Lan , SHORE, Daniel , DO, Steven , YUEN, Po-wai , HU, Baihua , WU, Guosheng , LIN, Xingyu , LU, Aijun
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D401/12 , C07D403/14 , C07D409/14 , C07D417/12 , C07D417/14 , A61K31/4025 , A61K31/402 , A61K31/4545 , A61P29/00 , A61P11/00 , A61P11/06 , A61P11/14 , A61P17/04 , A61P19/02 , A61P27/16
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07F9/6512
摘要： and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.
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5.发明公开5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS 审中-公开5-氯代-2-二氟甲氧基苯基 - 吡唑并嘧啶 - 维生素，DIE JAK-INHIBITOREN
公开(公告)号：EP3145929A1
公开(公告)日：2017-03-29
申请号：EP15726064.7
申请日：2015-05-22
发明人： ZAK, Mark Edward , RAY, Nicholas Charles , GOODACRE, Simon Charles , MENDONCA, Rohan , KELLAR, Terry , CHENG, Yun-Xing , LI, Wei , YUEN, Po-wai
IPC分类号： C07D487/04 , A61K31/519 , A61P11/06 , A61P29/00
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04 , C07D519/00
摘要： Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
摘要翻译： 本文描述了式（00A）的化合物和用作Janus激酶抑制剂的方法。
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公开(公告)号：EP3055302B1
公开(公告)日：2018-12-26
申请号：EP14789194.9
申请日：2014-10-09
发明人： CHEN, Huifen , CHU, Yanyan , DO, Steven , ESTRADA, Anthony , HU, Baihua , KOLESNIKOV, Aleksandr , LIN, Xingyu , LYSSIKATOS, Joseph P. , SHORE, Daniel , VERMA, Vishal , WANG, Lan , WU, Guosheng , YUEN, Po-wai
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D403/14 , C07D417/12 , C07D451/02 , C07D491/048 , C07D207/48 , A61K31/4025 , A61P29/00
CPC分类号： C07D207/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D451/02 , C07D491/048
摘要： and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
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公开(公告)号：EP3380474A1
公开(公告)日：2018-10-03
申请号：EP16798788.2
申请日：2016-11-23
发明人： CHENG, Yun-Xing , GIBBONS, Paul , KELLAR, Terry , LI, Wei , MENDONCA, Rohan , YUEN, Po-wai , ZAK, Mark Edward , ZHANG, Lei
IPC分类号： C07D487/04 , A61K31/519 , A61P11/06 , A61P29/00
CPC分类号： C07D487/04 , C07D519/00
摘要： Compounds of Formula (00A) and salts thereof, wherein R1, R2 R3, R4 and n are defined herein, are useful as inhibitors of one or more Janus kinases. Also provided are pharmaceutical compositions that include a compound of Formula (00A) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient. ( 00A)
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公开(公告)号：EP3596072A2
公开(公告)日：2020-01-22
申请号：EP18711294.1
申请日：2018-03-13
发明人： ZAK, Mark , ROMERO, F. Anthony , YUEN, Po-wai , HANAN, Emily J.
IPC分类号： C07D471/04 , C07D487/04 , C07D491/048 , C07D513/04 , A61K31/437 , A61P11/06
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公开(公告)号：EP3256463B1
公开(公告)日：2019-10-09
申请号：EP16703990.8
申请日：2016-02-12
发明人： ESTRADA, Anthony , VOLGRAF, Matthew , CHEN, Huifen , KOLESNIKOV, Aleksandr , VILLEMURE, Elisia , VERMA, Vishal , WANG, Lan , SHORE, Daniel , DO, Steven , YUEN, Po-wai , HU, Baihua , WU, Guosheng , LIN, Xingyu , LU, Aijun
IPC分类号： C07F9/6512 , C07D403/12 , C07D401/14 , C07D405/14 , C07D401/12 , C07D403/14 , C07D409/14 , C07D417/12 , C07D417/14
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10.发明公开SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS 审中-公开SUBSTITUIERTE HETEROCYCLISCHE SULFONAMIDVERBINDUNGEN ALS TRPA1-MODULATOREN
公开(公告)号：EP3055302A1
公开(公告)日：2016-08-17
申请号：EP14789194.9
申请日：2014-10-09
发明人： CHEN, Huifen , CHU, Yanyan , DO, Steven , ESTRADA, Anthony , HU, Baihua , KOLESNIKOV, Aleksandr , LIN, Xingyu , LYSSIKATOS, Joseph P. , SHORE, Daniel , VERMA, Vishal , WANG, Lan , WU, Guosheng , YUEN, Po-wai
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D403/14 , C07D417/12 , C07D451/02 , C07D491/048 , C07D207/48 , A61K31/4025 , A61P29/00
CPC分类号： C07D207/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D451/02 , C07D491/048
摘要： and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
摘要翻译： 本发明涉及式I或II的化合物及其盐。 此外，本发明涉及制备方法和使用式I或II化合物的方法以及含有这些化合物的药物组合物。 该化合物可用于治疗TRPA1介导的疾病和病症，例如疼痛。
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