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公开(公告)号：EP2809682B1
公开(公告)日：2020-04-08
申请号：EP13705405.2
申请日：2013-01-24
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2.发明公开BISPECIFIC ANTIBODY MOLECULES WITH ANTIGEN-TRANSFECTED T-CELLS AND THEIR USE IN MEDICINE 审中-公开具有抗原转染的T细胞和它们在医学双特异性抗体分子
公开(公告)号：EP2809682A1
公开(公告)日：2014-12-10
申请号：EP13705405.2
申请日：2013-01-24
发明人： BOURQUIN, Carole , CASTOLDI, Raffaella , ENDRES, Stefan , KLEIN, Christian , KOBOLD, Sebastian , NIEDERFELLNER, Gerhard , SUSTMANN, Claudio
摘要： The present invention relates to a bispecific (monoclonal) antibody molecule with a first binding domain binding an antigen on CD8+ T-cells that does not naturally occur in and/or on CD8+ T-cells and a second binding domain binding to a tumor specific antigen naturally occurring on the surface of a tumor cell. The bispecific (monoclonal) antibody molecules are particularly useful in combination with transduced CD8+ T-cells comprising an antigen which does not naturally occur in and/or on CD8+ T-cells and/or a T-cell receptor. The invention provides the use of said (bispecific) antibody molecules as a medicament, the (bispecific) antibody molecules for use in a method for the treatment of particular diseases as well as a pharmaceutical composition/medicament comprising said (bispecific) antibody molecules, wherein said (bispecific) antibody molecules are to be administered in combination with transduced CD8+ T-cells comprising an antigen which does not naturally occur in and/or on CD8+ T-cells and/or a T-cell receptor in a specific treatment regimen. Further aspects of the invention are nucleic acid sequences encoding said bispecific (monoclonal) antibody molecules, vectors. host cells, methods for the production of the (bispecific) antibody molecule as well as a kit comprising the (bispecific) antibody molecule of the invention.
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