公开(公告)号：EP4484924A1

公开(公告)日：2025-01-01

申请号：EP23190576.1

申请日：2023-08-09

Applicant: F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

Inventor： HILDENBRAND, Juergen ,  KRAMLICH, Alexander ,  LAMBERTSON, Michael

IPC: G01N21/15 ,  G01N21/31

Abstract: An in-vitro diagnostic (IVD) analyzer 200 comprising an optical detection unit 217 comprising a cuvette 214 for the optical measurement of a biological sample 2, 2' is herein disclosed. The IVD analyzer 200 further comprises a piezo actuator 218 arranged on one side of the cuvette 214 configured to transmit ultrasonic waves 254, 254' through the cuvette 214, a piezo receiver 218' arranged on the opposite side of the cuvette 214 configured to receive ultrasonic waves 255, 255', 255" transmitted through the cuvette 214, and a controller 250 configured to operate according to a lysis operating mode L and according to an air-detection operating mode AD. According to the lysis operating mode L the piezo actuator 218 is configured to transmit ultrasonic waves 254' through the cuvette 214 for disrupting cellular particles contained in the biological sample 2. According to the air-detection operating mode AD the piezo actuator 218 is configured to transmit ultrasonic waves 254 through the cuvette 214 and the controller 250 is configured to correlate changes in amplitude and/or shifts of phase of the ultrasonic waves 255, 255', 255" received by the piezo receiver 218' relative to reference values with an eventual presence and quantity of air 3 in the cuvette 214, in order to determine if the optical measurement of the biological sample 2, 2' is affected by the presence of air 3. A respective automated method of operating the in-vitro diagnostic analyzer 200 in order to determine if the optical measurement of the biological sample 2, 2' is affected by the presence of air is also disclosed.