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1.发明授权[1, 2, 3]TRIAZOLO [4, 5 -D]PYRIMIDINE DERIVATIVES AS AGONISTS OF THE CANNABINOID RECEPTOR 2 有权[1,2,3]三唑并[4,5-D]嘧啶衍生物作为大麻素受体2激动剂
公开(公告)号：EP2776442B1
公开(公告)日：2015-10-21
申请号：EP12780208.0
申请日：2012-11-05
发明人： ADAM, Jean-Michel , BISSANTZ, Caterina , GRETHER, Uwe , KIMBARA, Atushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark
IPC分类号： C07D487/04 , A61K31/519 , A61P3/10 , A61P9/10 , A61P27/06
CPC分类号： C07D487/04 , A61K9/0019 , A61K9/2054 , A61K9/4866 , A61K31/519 , A61K47/10 , C07D491/107
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2.发明公开(3,4-DICHLORO-PHENYL)-((S)-3-PROPYL-PYRROLIDIN-3-YL)-METHANONE HYDROCHLORIDE AND MANUFACTURING PROCESSES 有权（3,4-二氯苯基） - （（S）-3-丙基 - 吡咯烷-3-基） - 甲基 - 氢氯化物在HERSTELLUNGSVERFAHREN
公开(公告)号：EP2841418A1
公开(公告)日：2015-03-04
申请号：EP13718188.9
申请日：2013-04-23
发明人： ADAM, Jean-Michel , DVORAK, Charles Alois , FISHLOCK, Daniel , HUMPHREYS, Eric R. , IDING, Hans , PFLEGER, Christophe , REGE, Pankaj D. , SHI, Xianqing , VITALE, Justin , WANG, Shaoning , ZAJAC, Marian
IPC分类号： C07D207/08 , A61K31/40 , A61P25/22 , A61P25/24
CPC分类号： C07D207/08
摘要： The present invention is concerned with a novel process for the preparation of a compound of formula I and its hydrates, as well as with a crystall polymorph thereof. The compounds of formula (I) and the corresponding hydrates are pharmaceutically active substances.
摘要翻译： 式I化合物和相应的水合物是药物活性物质。
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3.发明公开[1, 2, 3]TRIAZOLO [4, 5 -D]PYRIMIDINE DERIVATIVES AS AGONISTS OF THE CANNABINOID RECEPTOR 2 有权[1,2,3]三唑并[4,5-D]嘧啶衍生物作为大麻素受体2激动剂
公开(公告)号：EP2776442A1
公开(公告)日：2014-09-17
申请号：EP12780208.0
申请日：2012-11-05
发明人： ADAM, Jean-Michel , BISSANTZ, Caterina , GRETHER, Uwe , KIMBARA, Atushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark
IPC分类号： C07D487/04 , A61K31/519 , A61P3/10 , A61P9/10 , A61P27/06
CPC分类号： C07D487/04 , A61K9/0019 , A61K9/2054 , A61K9/4866 , A61K31/519 , A61K47/10 , C07D491/107
摘要： The invention relates to a compound of formula (I), wherein A, R
1 and R
2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament as agonists of the cannabinoid receptor 2.
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