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公开(公告)号：EP1919913A2
公开(公告)日：2008-05-14
申请号：EP06778249.0
申请日：2006-08-16
发明人： ARORA, Nidhi , ARZENO, Humberto Bartolome , BILLEDEAU, Roland Joseph , DEWDNEY, Nolan James , DURKIN, Kieran , GABRIEL, Tobias , MCCALEB, Kristen Lynn , SOTH, Michael , YASUDA, Dennis Mitsugu
IPC分类号： C07D487/04 , C07D231/56 , C07D471/04 , C07D413/12 , A61K31/4162
CPC分类号： C07D471/04 , C07D231/56 , C07D413/12 , C07D487/04
摘要： Compounds of formula Ia or Ib; wherein A, W, X, Y, R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
摘要翻译： 式Ia或Ib化合物; 其中A，W，X，Y，R 1，R 2，R 3和R 4如本文所定义。 还公开了制备所述化合物的方法和使用所述化合物治疗p38 MAP激酶介导的疾病的方法。
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公开(公告)号：EP1919470A1
公开(公告)日：2008-05-14
申请号：EP06764330.4
申请日：2006-08-15
发明人： ARORA, Nidhi , BILLEDEAU, Roland Joseph , DEWDNEY, Nolan James , GABRIEL, Tobias , GOLDSTEIN, David Michael , O'YANG, Counde , SOTH, Michael , TREJO-MARTIN, Teresa Alejandra
IPC分类号： A61K31/4162 , C07D471/04 , C07D487/04 , A61P29/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Fused pyrazoles effective as p38 MAP kinase inhibitors, methods of making the compounds, and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
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公开(公告)号：EP1747202A1
公开(公告)日：2007-01-31
申请号：EP05707563.2
申请日：2005-02-22
IPC分类号： C07D231/56 , A61K31/416 , A61P25/28 , A61P29/00
CPC分类号： C07D231/56
摘要： Compounds of Formula (I), or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, k, B, R1, R2 and R3 are those defined herein, and compositions comprising the same. Also provided are methods for preparing compounds of formula (I) and using the same in treating p38 mediated disorders in a patient.
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公开(公告)号：EP1720878A1
公开(公告)日：2006-11-15
申请号：EP05715442.9
申请日：2005-02-22
发明人： ARORA, Nidhi , BILLEDEAU, Roland, J. , DEWDNEY, Nolan, James , GABRIEL, Tobias , GOLDSTEIN, David, Michael , SOTH, Michael , TREJO-MARTIN, Teresa, Alejandra , MCCALEB, Kristen, Lynn
IPC分类号： C07D487/04 , C07D471/04 , A61K31/4162 , A61K31/4985 , A61K31/519 , A61P19/02 , A61P25/28 , C07D239/00 , C07D231/00 , C07D241/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of formula (I): where A, B, X, Y, Z, k, R1, R2 and R3 are those defined herein, and compositions comprising the same. The present invention also provides methods for preparing compounds of formula (I) and using the same in treating p38 mediated disorders in a patient.
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5.发明公开PYRAZOLO [1, 5A]PYRIMIDINE AND THIENO [3, 2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS 有权吡咯并[1,5A]吡啶并[3,2,2]嘌呤霉素衍生物，IRAK4-MODULATOREN
公开(公告)号：EP2593457A1
公开(公告)日：2013-05-22
申请号：EP11736028.9
申请日：2011-07-08
发明人： ARORA, Nidhi , CHEN, Shaoqing , HERMANN, Johannes, Cornelius , KUGLSTATTER, Andreas , LABADIE, Sharada, Shenvi , LIN, Clara Jeou Jen , LUCAS, Matthew, C. , MOORE, Amy, Geraldine , PAPP, Eva , TALAMAS, Francisco, Xavier , WANNER, Jutta , ZHAI, Yansheng
IPC分类号： C07D487/04 , C07D495/04 , A61K31/4365 , A61K31/519 , A61P11/00 , A61P29/00
CPC分类号： C07D495/04 , C07D487/04
摘要： Compounds of the formula I or II: wherein X, m, Ar, R
1 and R
2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.摘要翻译： 式I或II的化合物：其中X，m，Ar，R 1和R 2如本文所定义。 本发明化合物可用于治疗IRAK介导的病症。
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公开(公告)号：EP1737865A1
公开(公告)日：2007-01-03
申请号：EP05707608.5
申请日：2005-02-24
发明人： ARORA, Nidhi , BILLEDEAU, Roland, J. , DEWDNEY, Nolan, James , GABRIEL, Tobias , GOLDSTEIN, David, Michael , O'YANG, Counde , SOTH, Michael
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Compounds of the formula (Ia), (Ib) or (Ic), wherein A, B, X, Y, Z, W, k, R1, R2, R3, R4 and R5 are those defined herein, and compositions comprising the same. The present invention also provides methods for preparing said compounds and using the same in treating p38 mediated disorders in a subject.
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