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33 条记录 (耗时 0.021 秒)

    TRIAZOLOPYRIDINE COMPOUNDS AS PDE10A INHIBITORS
    6.
    发明公开
    TRIAZOLOPYRIDINE COMPOUNDS AS PDE10A INHIBITORS 有权
    TRIZZOLOPYRIDINE化合物作为PDE10A抑制剂

    公开(公告)号：EP2758396A1

    公开(公告)日：2014-07-30

    申请号：EP12759445.5

    申请日：2012-09-17

    申请人： F.Hoffmann-La Roche AG

    发明人： FLOHR, Alexander ,  GROEBKE ZBINDEN, Katrin ,  KOERNER, Matthias

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P25/00

    CPC分类号： C07D471/04

    摘要： The invention is concerned with triazolopyridine compounds of formula (I) wherein R
    1 , R
    2 and R
    3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.

    摘要翻译： 本发明涉及式（I）的三唑并吡啶化合物及其生理学上可接受的盐，其中R 1，R 2和R 3如说明书和权利要求书中所定义。 这些化合物抑制PDE10A并可用作药物。

    USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS
    7.
    发明授权
    USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS 有权
    4-咪唑衍生物用于CNS疾病中的用途

    公开(公告)号：EP1981880B1

    公开(公告)日：2010-02-24

    申请号：EP07703939.4

    申请日：2007-01-17

    申请人： F.HOFFMANN-LA ROCHE AG

    发明人： GALLEY, Guido ,  GROEBKE ZBINDEN, Katrin ,  HOENER, Marius ,  NORCROSS, Roger ,  STALDER, Henri

    IPC分类号： C07D405/06 ,  C07D233/54 ,  A61K31/4174 ,  A61K31/4178 ,  A61P25/00

    CPC分类号： C07D233/64 ,  C07D405/06

    摘要： The present invention relates to the use of compounds of formula (I) wherein R is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, phenyl, S-phenyl or O-phenyl, which are optionally substituted by lower alkoxy or halogen, or is benzyloxy, C(O)O-lower alkyl, cycloalkyl, or is lower alkyl or lower alkoxy substituted by halogen; Ar is aryl or heteroaryl, selected from the group consisting of phenyl, naphthyl, pyridinyl, benzofuranyl, dihydrobenzofuranyl or pyrazole; R1/R1' are independently from each other hydrogen, hydroxy, lower alkyl, lower alkoxy or are phenyl or benzyl, which are optionally substituted by halogen; R2 is hydrogen or lower alkyl; n is 1, 2, 3 or 4; and to their pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms for the preparation of medicaments for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

    USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES
    8.
    发明公开
    USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES 审中-公开
    USE取代的2-咪唑OFF咪唑啉衍生物

    公开(公告)号：EP1981497A2

    公开(公告)日：2008-10-22

    申请号：EP07703941.0

    申请日：2007-01-17

    申请人： F.HOFFMANN-LA ROCHE AG

    发明人： GALLEY, Guido ,  GROEBKE ZBINDEN, Katrin ,  HOENER, Marius ,  KOLCZEWSKI, Sabine ,  NORCROSS, Roger ,  STALDER, Henri

    IPC分类号： A61K31/4164 ,  A61K31/4174 ,  C07D233/06 ,  C07D233/54 ,  C07D401/04 ,  C07D405/06 ,  C07D409/06 ,  A61P25/00

    CPC分类号： C07D233/06 ,  A61K31/4164 ,  A61K31/4178 ,  C07D233/20 ,  C07D233/22 ,  C07D233/56 ,  C07D233/64 ,  C07D401/10 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06

    摘要： The present invention relates to the use of compounds of Formula (I), wherein R is hydrogen, tritium, hydroxy, amino, lower alkyl, cycloalkyl, lower alkoxy, halogen, cyano, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, phenyl, O-phenyl, -S-phenyl, optionally substituted by halogen, or is benzyl, benzyloxy, NHC(O)-lower alkyl or pyridin-2,3 or 4-yl; R1 is hydrogen, hydroxy or lower alkyl; R2 is hydrogen or lower alkyl; aryl is an aromatic group, selected from phenyl, naphthalen-1-yl or naphthalen-2-yl; hetaryl is an aromatic group, containing at least one O, N or S ring atom, selected from the group consisting of pyridine-3-yl, pyrazolyl, benzofuran-3-yl, benzofuran-4-yl, benzofuran-5-yl, benzofuran-6-yl, benzofuran-7-yl, thiophen-2-yl, thiophen-3-yl, benzo[b]thiophen-3-yl or indol-3-yl; n is 1, 2, 3, 4 or 5; when n is 2, 3, 4 or 5, R may be the same or not; the dotted line may be a bond or not; and to their pharmaceutically active salts for the preparation of medicaments for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.