专利检索 ap:("F.Hoffmann-La Roche AG") AND inv:"O'BRIEN, Erin, M." 第 1 页

1.

发明授权
2-AMINO-PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF JNK 有权
标题翻译： AS JNK抑制剂合适的2-氨基嘧啶衍生物

公开(公告)号：EP2576537B1

公开(公告)日：2016-03-16

申请号：EP11723059.9

申请日：2011-06-01

申请人： F.Hoffmann-La Roche AG

发明人： ARZENO, Humberto, Bartolome , FILONOVA, Lubov , GOLDSTEIN, David, Michael , GONG, Leyi , LOE, Bradley, E. , O'BRIEN, Erin, M. , PALMER, Wylie, Solang , ROTSTEIN, David, Mark , SILVA, Tania , TAN, Yun-chou

IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D487/02 , A61K31/506 , A61P3/10 , A61P11/06 , A61P19/02 , A61P29/00

CPC分类号： C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D409/14 , C07D487/02

2.

发明公开
2 -AMINO- PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF JNK 有权
标题翻译： AS JNK抑制剂合适的2-氨基嘧啶衍生物

公开(公告)号：EP2576537A1

公开(公告)日：2013-04-10

申请号：EP11723059.9

申请日：2011-06-01

申请人： F.Hoffmann-La Roche AG

发明人： ARZENO, Humberto, Bartolome , FILONOVA, Lubov , GOLDSTEIN, David, Michael , GONG, Leyi , LOE, Bradley, E. , O'BRIEN, Erin, M. , PALMER, Wylie, Solang , ROTSTEIN, David, Mark , SILVA, Tania , TAN, Yun-chou

IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D487/02 , A61K31/506 , A61P3/10 , A61P11/06 , A61P19/02 , A61P29/00

CPC分类号： C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D409/14 , C07D487/02

摘要： Compounds of formula I or pharmaceutically acceptable salts thereof, wherein R
5 is a group of formula (a) or (b): and wherein m, n, p, q, X, Y, R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 and R
9 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity.