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1.发明公开PROPANE- I-SULFONIC ACID {3- [5- (4 -CHLORO-PHENYL) -1H-PYRROLO [2, 3-B] PYRIDINE-3-CARBONYL] -2, 4-DIFLUORO-PHENY L } -AMIDE COMPOSITIONS AND USES THEREOF 有权丙烷-1-磺酸{3- [5-（4-氯苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基] -2,4-二氟苯基}酰胺的组合物及其应用
公开(公告)号：EP2414356A2
公开(公告)日：2012-02-08
申请号：EP10722860.3
申请日：2010-03-31
发明人： DESAI, Dipen , DIODONE, Ralph , GO, Zenaida , IBRAHIM, Prabha, N. , IYER, Raman, Mahadevan , MAIR, Hans-Juergen , SANDHU, Harpreet, K. , SHAH, Navnit, Hargovindas , VISOR, Gary, Conard , WYTTENBACH, Nicole , LAUPER, Stephan , PUDEWELL, Johannes , WIERSCHEM, Frank
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
摘要： Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1 -sulfonic acid {3-[5-(4-chloro-pheny!)-lH-pyrrolo[2,3-b]pyridine-3-carbonyl]- 2,4-difluoro-phenyl} -amide. (Formula I).
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2.发明授权PROPANE-I-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF 有权丙烷-1-磺酸{3- [5-（4-氯苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基] -2,4-二氟苯基}酰胺的组合物及其应用
公开(公告)号：EP2414356B1
公开(公告)日：2015-09-02
申请号：EP10722860.3
申请日：2010-03-31
发明人： DESAI, Dipen , DIODONE, Ralph , GO, Zenaida , IBRAHIM, Prabha, N. , IYER, Raman, Mahadevan , MAIR, Hans-Juergen , SANDHU, Harpreet, K. , SHAH, Navnit, Hargovindas , VISOR, Gary, Conard , WYTTENBACH, Nicole , LAUPER, Stephan , PUDEWELL, Johannes , WIERSCHEM, Frank
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
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公开(公告)号：EP1928427A1
公开(公告)日：2008-06-11
申请号：EP06793473.7
申请日：2006-09-13
IPC分类号： A61K9/20 , A61K31/44 , A61K31/455 , A61K31/4427
CPC分类号： C07D413/04 , A61K9/1641 , A61K9/1694 , A61K9/2031 , A61K9/2077 , A61K9/2095 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/455
摘要： The invention relates to a process for preparing a pharmaceutical tablet composition, wherein the active pharmaceutical ingredient of formula (I) wherein the definitions are described in claim 1 or pharmaceutically acceptable acid addition salts thereof and a water soluble poloxamer are together processed by hot melt extrusion before mixing with the other ingredients, and wherein the tablet composition may thereafter be coated with a composition comprising an immediate release film coating system and purified water. The invention related also to pharmaceutical compositions, prepared by such method.
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公开(公告)号：EP1928427B1
公开(公告)日：2009-12-30
申请号：EP06793473.7
申请日：2006-09-13
IPC分类号： A61K9/20 , A61K31/44 , A61K31/455 , A61K31/4427
CPC分类号： C07D413/04 , A61K9/1641 , A61K9/1694 , A61K9/2031 , A61K9/2077 , A61K9/2095 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/455
摘要： The invention relates to a process for preparing a pharmaceutical tablet composition, wherein the active pharmaceutical ingredient of formula (I) wherein the definitions are described in claim 1 or pharmaceutically acceptable acid addition salts thereof and a water soluble poloxamer are together processed by hot melt extrusion before mixing with the other ingredients, and wherein the tablet composition may thereafter be coated with a composition comprising an immediate release film coating system and purified water. The invention related also to pharmaceutical compositions, prepared by such method.
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5.发明公开PHARMACEUTICAL COMPOSITION WITH IMPROVED BIOAVAILABILITY FOR HIGH MELTING HYDROPHOBIC COMPOUND 有权具有生物利用度改善药物组合物，熔点高防水连接
公开(公告)号：EP2790699A1
公开(公告)日：2014-10-22
申请号：EP12801538.5
申请日：2012-12-10
发明人： ALBANO, Antonio, A. , DESAI, Dipen , DINUNZIO, James , GO, Zenaida , IYER, Raman, Mahadevan , SANDHU, Harpreet, K. , SHAH, Navnit, Hargovindas
IPC分类号： A61K31/437 , A61K31/4745 , A61K31/506 , A61K9/14 , A61K9/20 , A61K47/32 , A61K47/38 , A61P35/00
摘要： The present invention relates to a pharmaceutical composition comprising a solid dispersion of a drug. In the composition, the drug is in substantially amorphous form.
摘要翻译： 本发明涉及包含药物的固体分散体的药物组合物。 在该组合物中，药物是在基本上无定形的形式。
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