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    Ergoline derivatives
    1.
    发明公开
    Ergoline derivatives 失效
    ERGOLINE衍生物

    公开(公告)号：EP0296830A3

    公开(公告)日：1989-12-06

    申请号：EP88305695.4

    申请日：1988-06-22

    申请人： FARMITALIA CARLO ERBA S.r.l.

    发明人： Mantegani, Sergio ,  Brambilla, Enzo ,  Temperilli, Aldemio ,  Ruggieri, Daniela ,  Salvati, Patricia

    IPC分类号： C07D457/02 ,  C07D457/12 ,  A61K31/48

    CPC分类号： C07D457/12 ,  C07D457/02

    摘要： An ergoline derivative of formula I:
    wherein R₁ represents a hydrogen atom or a methyl group; R₂ represents a hydrogen or halogen atom, a methyl, cyano or phenyl group or an alkylthio group having from 1 to 4 carbon atoms; R₃ represents a hydrocarbon group having from 1 to 4 carbon atoms; R₄ represents a hydrogen atom, a phenyl group or a hydrocarbon group having from1 to 4 carbon atoms; either (a) each of R₆ and R₇ represents a hydrogen atom or, taken together, R₆ and R₇ represent a valence bond and R₈ represents a hydrogen atom or a methoxy group, or (b) R₆ represents a hydrogen atom and R₇ and R₈ taken together represent a valence bond; W represents an oxygen atom or an imino group; A represents a group of the formula CHR₅, CH=CR₅ or CH₂CHR₅ wherein R₅ represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms; X represents an oxygen or sulphur atom or an imino group; and n is 0, 1 or 2; or a pharmaceutically acceptable salt of such ergoline derivative; is an antihypertensive agent.

    Ergoline derivatives
    3.
    发明公开
    Ergoline derivatives 失效
    Ergolin衍。

    公开(公告)号：EP0296830A2

    公开(公告)日：1988-12-28

    申请号：EP88305695.4

    申请日：1988-06-22

    申请人： FARMITALIA CARLO ERBA S.r.l.

    发明人： Mantegani, Sergio ,  Brambilla, Enzo ,  Temperilli, Aldemio ,  Ruggieri, Daniela ,  Salvati, Patricia

    IPC分类号： C07D457/02 ,  C07D457/12 ,  A61K31/48

    CPC分类号： C07D457/12 ,  C07D457/02

    摘要： An ergoline derivative of formula I:
    wherein R₁ represents a hydrogen atom or a methyl group; R₂ represents a hydrogen or halogen atom, a methyl, cyano or phenyl group or an alkylthio group having from 1 to 4 carbon atoms; R₃ represents a hydrocarbon group having from 1 to 4 carbon atoms; R₄ represents a hydrogen atom, a phenyl group or a hydrocarbon group having from1 to 4 carbon atoms; either (a) each of R₆ and R₇ represents a hydrogen atom or, taken together, R₆ and R₇ represent a valence bond and R₈ represents a hydrogen atom or a methoxy group, or (b) R₆ represents a hydrogen atom and R₇ and R₈ taken together represent a valence bond; W represents an oxygen atom or an imino group; A represents a group of the formula CHR₅, CH=CR₅ or CH₂CHR₅ wherein R₅ represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms; X represents an oxygen or sulphur atom or an imino group; and n is 0, 1 or 2; or a pharmaceutically acceptable salt of such ergoline derivative; is an antihypertensive agent.

    摘要翻译： 式I的麦角灵衍生物：其中R 1表示氢原子或甲基; R 2表示氢或卤素原子，甲基，氰基或苯基或具有1至4个碳原子的烷硫基; R3表示具有1至4个碳原子的烃基; R4代表氢原子，苯基或具有1-4个碳原子的烃基; （a）R6和R7各自表示氢原子，或者一起R6和R7表示价键，R8表示氢原子或甲氧基，或（b）R6表示氢原子，R7和R8表示 共同代表价债; W表示氧原子或亚氨基; A表示式CHR 5，CH = CR 5或CH 2 CHR 5的基团，其中R 5表示氢原子或具有1至4个碳原子的烷基; X表示氧或硫原子或亚氨基; 并且n为0,1或2; 或这种麦角灵衍生物的药学上可接受的盐; 是抗高血压药。

    Ergoline derivatives, processes for their preparation and pharmaceutical compositions containing same
    5.
    发明公开
    Ergoline derivatives, processes for their preparation and pharmaceutical compositions containing same 失效
    麦角灵衍生物，其制备方法和含有它们的药物组合物。

    公开(公告)号：EP0126968A1

    公开(公告)日：1984-12-05

    申请号：EP84104568.5

    申请日：1984-04-24

    申请人： FARMITALIA CARLO ERBA S.r.l.

    发明人： Bernardi, Luigi ,  Chiodini, Laura ,  Mantegani, Sergio ,  Ruggieri, Daniela ,  Temperilli, Aldemio ,  Salvati, Patricia

    IPC分类号： C07D457/00 ,  C07D457/12 ,  C07D457/02 ,  A61K31/48

    CPC分类号： C07D457/02 ,  C07D457/12

    摘要： R 1 =H, CH 3
    R 2 =H, halogen, CH 3 , CN, lower alkylthio, phenylthio
    R 7 and R 8 =H; R 3 =H, OCH 3
    R 7 =H, R 3 and R s = bond
    R 7 and R 8 =bond, R 3 =H, OCH 3
    R 4 =C 1 -C 4 hydrocarbon
    R s =H, C 1 -C 4 hydrocarbon, phenyl
    A=CHR 6 , CH 2 CHR 6 , CH=CR 6
    R 6 =H, lower alkyl
    n=O, 1, 2
    X=O,S,NH B=CN, COOalK. CONH 2
    R 9 =H or B and R 9 =-C=W
    W=O,NH

    and their pharmaceutically acceptable salts are antiprolacti- nic and antihypertensive agents. Their preparation and pharmaceutical compositions containing them are also described.

    摘要翻译： ... ... R1 = H，CH3 ... R2 = H，卤素，CH 3，CN，低级烷硫基，苯硫基... ... R4 = C1-C4烃... R5 = H，C1-C4烃，苯基... A = CHR6，CH2CHR6，CH = CR 6 ... R6 = H，=低级烷基，...，N 0，1，2 ... X = O，S，NH B = CN，COOalk，CONH 2 ... R9 = H或B和R9 = -C = W ... W = O，NH ...和它们的药学上可接受的盐是抗催乳素和抗高血压剂。 含有这些制剂和药物组合物如此描述。