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1.发明公开METHOD FOR TREATING OR PREVENTING ISCHEMIA REPERFUSION INJURY OR MULTI-ORGAN FAILURE 有权方法治疗或预防缺血再灌注损伤或多器官衰竭
公开(公告)号：EP1933861A4
公开(公告)日：2009-07-01
申请号：EP06794084
申请日：2006-09-22
发明人： JALKANEN SIRPA
IPC分类号： A61K38/21 , A61K20060101 , A61P29/00 , C07K14/565
CPC分类号： C07K14/565 , A61K38/215 , A61K2300/00
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2.发明公开A NOVEL CELL AND THERAPEUTICAL AND DIAGNOSTICAL METHODS BASED THEREON 有权NEUARTIGE ZELLE SOWIE THERAPIE- UND DIAGNOSEVERFAHRENDAFÜR
公开(公告)号：EP2421888A4
公开(公告)日：2013-03-06
申请号：EP10766694
申请日：2010-04-06
发明人： JALKANEN SIRPA , SALMI MARKO , JALKANEN MARKKU
IPC分类号： C07K14/05 , A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C12N15/1138 , A61K31/58 , A61K35/15 , A61K38/17 , A61K38/202 , A61K38/2026 , A61K2039/505 , C07K16/28 , C12N15/115 , C12Q1/6883 , C12Q1/6886
摘要： The invention relates to a novel cell derived from the human body, where said cell comprises a Clever-1 receptor; to a method for affecting the immune system of an individual and for treatment of diseases or conditions related to the function of the immune system and to methods for screening of cancer patients that may respond to an anti-Clever-1 therapy or for diagnosing of a pregnancy complication or for estimating the risk of such complication in a pregnant woman.
摘要翻译： 本发明涉及一种衍生自人体的新型细胞，其中所述细胞包含Clever-1受体; 涉及一种影响个体的免疫系统和用于治疗与免疫系统的功能相关的疾病或病症的方法，以及用于筛选可能对抗Clever-1疗法作出反应的癌症患者的方法或用于诊断 怀孕并发症或估计孕妇出现并发症的风险。
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3.发明公开A NEW BIOMARKER FOR MONITORING DEVELOPMENT OF DISEASES AND ASSESSING THE EFFICACY OF THERAPIES 有权的新生物标记的用于监测发展的疾病，并进行治疗试验的有效性
公开(公告)号：EP2201376A4
公开(公告)日：2011-03-23
申请号：EP08842581
申请日：2008-10-15
发明人： JALKANEN SIRPA , SALMI MARKO , JALKANEN MARKKU
IPC分类号： G01N33/573 , C07K14/705 , C12N9/16 , G01N33/574
CPC分类号： G01N33/57484 , G01N2333/70596 , G01N2800/245 , G01N2800/324 , G01N2800/56
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4.发明公开A METHOD FOR DETERMINING ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) RELATED BIOMARKERS, A METHOD TO MONITOR THE DEVELOPMENT AND TREATMENT OF ARDS IN A PATIENT 有权方法用于确定用于急性进行肺衰竭和方法生物标记用于监控患者急性呼吸窘迫综合征的发展和治疗
公开(公告)号：EP2956772A4
公开(公告)日：2016-09-14
申请号：EP14752032
申请日：2014-01-22
发明人： MAKSIMOW MIKAEL , SALMI MARKO , JALKANEN MARKKU , JALKANEN SIRPA
IPC分类号： G01N33/573 , A61K38/21 , C07K14/565 , C07K14/705 , C12N9/16 , G01N30/90 , G01N33/68
CPC分类号： G01N33/573 , A61K38/215 , G01N30/90 , G01N33/6884 , G01N33/6893 , G01N2333/70596 , G01N2333/916 , G01N2800/125 , G01N2800/52 , G01N2800/60
摘要： This invention concerns methods for monitoring the development of and for treatment of ARDS in a patient. The method for monitoring the development of ARDS is based on comparing the level or activity of the biomarkers obtained in a sample drawn at a later point of time to the levels or activities of the same biomarkers in a sample drawn at a previous point of time. A favourable change in the level or activity of a certain biomarker represents a regression of the disease (recovery of the patient), and, conversely, an adverse change in the level or activity of a certain biomarker represents a worsening of the disease. If, for example, the level or activity for one or more of the biomarkers monitored discontinues to show a favourable change or starts to show an unfavourable change, the treatment of the patient is enhanced by administering a therapeutically active agent useful in the treatment of ARDS. The invention concerns further a method for simultaneous determination of a multiple of biomarkers in a sample from a patient, wherein said biomarkers are related to ARDS. The level or the activity of the biomarkers is determined. The invention also concerns a diagnostic kit useful for carrying out the method, particularly a kit comprising a chip, such as a microarray suitable for use in biochip technology.
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5.发明公开COMPOUNDS FOR TREATING OR PREVENTING AMINE OXIDASE RELATED DISEASES OR DISORDERS 审中-公开用于治疗或与关联方防治化合物胺氧化酶的疾病或障碍
公开(公告)号：EP1890711A4
公开(公告)日：2010-08-18
申请号：EP06764414
申请日：2006-06-12
发明人： JALKANEN SIRPA , JALKANEN MARKKU , SALMI MARKO
IPC分类号： A61K31/7088 , C07H21/02 , C12N20060101 , C12N9/06 , C12N15/113
CPC分类号： C12N15/1138 , C12N2310/14 , C12Y104/03021
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