公开(公告)号：EP1294700A2

公开(公告)日：2003-03-26

申请号：EP01943821.7

申请日：2001-06-25

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： TAKE, Kazuhiko,Fujisawa Pharm. Co., Ltd ,  KASAHARA, Chiyoshi,Fujisawa Pharm. Co., Ltd ,  SHIGENAGA, Shinji,Fujisawa Pharm. Co., Ltd ,  AZAMI, Hidenori,Fujisawa Pharm. Co., Ltd ,  EIKYU, Yoshiteru,Fujisawa Pharm. Co., Ltd ,  NAKAI, Kazuo,Fujisawa Pharm. Co., Ltd ,  MORITA, Masataka,Fujisawa Pharm. Co., Ltd

IPC分类号： C07D241/04 ,  C07D241/08 ,  C07D487/04 ,  A61K31/4965 ,  A61P11/06

CPC分类号： C07D265/30 ,  C07C45/71 ,  C07D241/04 ,  C07D241/08 ,  C07D403/10 ,  C07D487/04 ,  C07C47/575

摘要： A compound of the formula (I): in which Z, R?1, R2, R8, R10, R11, R12, R13 and R14¿ are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.